Wong TW - Search Results

1

Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families.

Wong TW, Lee FY, Emanuel S, Fairchild C, Fargnoli J, Fink B, Gavai A, Hammell A, Henley B, Hilt C, Hunt JT, Krishnan B, Kukral D, Lewin A, Malone H, Norris D, Oppenheimer S, Vite G, Yu C. Wong TW, et al. Clin Cancer Res. 2011 Jun 15;17(12):4031-41. doi: 10.1158/1078-0432.CCR-10-3417. Epub 2011 Apr 29. Clin Cancer Res. 2011. PMID: 21531814

2

Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling.

Wong TW, Lee FY, Yu C, Luo FR, Oppenheimer S, Zhang H, Smykla RA, Mastalerz H, Fink BE, Hunt JT, Gavai AV, Vite GD. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93. doi: 10.1158/1078-0432.CCR-06-0642. Clin Cancer Res. 2006. PMID: 17062696

3

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

Gavai AV, Fink BE, Fairfax DJ, Martin GS, Rossiter LM, Holst CL, Kim SH, Leavitt KJ, Mastalerz H, Han WC, Norris D, Goyal B, Swaminathan S, Patel B, Mathur A, Vyas DM, Tokarski JS, Yu C, Oppenheimer S, Zhang H, Marathe P, Fargnoli J, Lee FY, Wong TW, Vite GD. Gavai AV, et al. Among authors: wong tw. J Med Chem. 2009 Nov 12;52(21):6527-30. doi: 10.1021/jm9010065. J Med Chem. 2009. PMID: 19821562

4

Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Fink BE, Norris D, Mastalerz H, Chen P, Goyal B, Zhao Y, Kim SH, Vite GD, Lee FY, Zhang H, Oppenheimer S, Tokarski JS, Wong TW, Gavai AV. Fink BE, et al. Among authors: wong tw. Bioorg Med Chem Lett. 2011 Jan 15;21(2):781-5. doi: 10.1016/j.bmcl.2010.11.100. Epub 2010 Nov 30. Bioorg Med Chem Lett. 2011. PMID: 21177105

5

Discovery of the pyrrolo[2,1-f][1,2,4]triazine nucleus as a new kinase inhibitor template.

Hunt JT, Mitt T, Borzilleri R, Gullo-Brown J, Fargnoli J, Fink B, Han WC, Mortillo S, Vite G, Wautlet B, Wong T, Yu C, Zheng X, Bhide R. Hunt JT, et al. J Med Chem. 2004 Jul 29;47(16):4054-9. doi: 10.1021/jm049892u. J Med Chem. 2004. PMID: 15267243

6

Apoptotic and cytostatic farnesyltransferase inhibitors have distinct pharmacology and efficacy profiles in tumor models.

Manne V, Lee FY, Bol DK, Gullo-Brown J, Fairchild CR, Lombardo LJ, Smykla RA, Vite GD, Wen ML, Yu C, Wong TW, Hunt JT. Manne V, et al. Among authors: wong tw. Cancer Res. 2004 Jun 1;64(11):3974-80. doi: 10.1158/0008-5472.CAN-03-3849. Cancer Res. 2004. PMID: 15173010

7

Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.

Marathe P, Tang Y, Sleczka B, Rodrigues D, Gavai A, Wong T, Christopher L, Zhang H. Marathe P, et al. J Pharm Sci. 2010 Aug;99(8):3579-93. doi: 10.1002/jps.22099. J Pharm Sci. 2010. PMID: 20166197

8

Prediction of active drug plasma concentrations achieved in cancer patients by pharmacodynamic biomarkers identified from the geo human colon carcinoma xenograft model.

Luo FR, Yang Z, Dong H, Camuso A, McGlinchey K, Fager K, Flefleh C, Kan D, Inigo I, Castaneda S, Wong TW, Kramer RA, Wild R, Lee FY. Luo FR, et al. Among authors: wong tw. Clin Cancer Res. 2005 Aug 1;11(15):5558-65. doi: 10.1158/1078-0432.CCR-05-0368. Clin Cancer Res. 2005. PMID: 16061873

9

Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics.

Kellar KA, Lorenzi MV, Ho CP, You D, Wen ML, Ryseck RP, Oppenheimer S, Fink BE, Vite GD, Rowley BR, Yu C, Bol DK, Lee FY, Wong TW. Kellar KA, et al. Among authors: wong tw. Mol Cancer Ther. 2006 Jun;5(6):1571-6. doi: 10.1158/1535-7163.MCT-06-0078. Mol Cancer Ther. 2006. PMID: 16818516

10

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Mastalerz H, Chang M, Chen P, Dextraze P, Fink BE, Gavai A, Goyal B, Han WC, Johnson W, Langley D, Lee FY, Marathe P, Mathur A, Oppenheimer S, Ruediger E, Tarrant J, Tokarski JS, Vite GD, Vyas DM, Wong H, Wong TW, Zhang H, Zhang G. Mastalerz H, et al. Among authors: wong h, wong tw. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2036-42. doi: 10.1016/j.bmcl.2007.01.002. Epub 2007 Jan 12. Bioorg Med Chem Lett. 2007. PMID: 17270437

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