Hruby VJ - Search Results

1

[D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.

Toth G, Kramer TH, Knapp R, Lui G, Davis P, Burks TF, Yamamura HI, Hruby VJ. Toth G, et al. Among authors: hruby vj. J Med Chem. 1990 Jan;33(1):249-53. doi: 10.1021/jm00163a041. J Med Chem. 1990. PMID: 2153205

2

Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.

Lee YS, Agnes RS, Badghisi H, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Lee YS, et al. Among authors: hruby vj. J Med Chem. 2006 Mar 9;49(5):1773-80. doi: 10.1021/jm050851n. J Med Chem. 2006. PMID: 16509592 Free PMC article.

3

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.

Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Agnes RS, et al. Among authors: hruby vj. J Med Chem. 2006 May 18;49(10):2868-75. doi: 10.1021/jm050921q. J Med Chem. 2006. PMID: 16686530 Free PMC article.

4

Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.

Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Lee YS, et al. Among authors: hruby vj. J Med Chem. 2007 Jan 11;50(1):165-8. doi: 10.1021/jm061268p. J Med Chem. 2007. PMID: 17201419 Free PMC article.

5

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.

Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Lee YS, et al. Among authors: hruby vj. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2161-5. doi: 10.1016/j.bmcl.2007.01.114. Epub 2007 Feb 8. Bioorg Med Chem Lett. 2007. PMID: 17329100 Free PMC article.

6

Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.

Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: hruby vj. J Med Chem. 2007 Jun 14;50(12):2779-86. doi: 10.1021/jm061369n. Epub 2007 May 22. J Med Chem. 2007. PMID: 17516639 Free PMC article.

7

Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.

Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Lee YS, et al. Among authors: hruby vj. J Med Chem. 2007 Nov 1;50(22):5528-32. doi: 10.1021/jm061465o. Epub 2007 Oct 10. J Med Chem. 2007. PMID: 17927164 Free PMC article.

8

A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: hruby vj. J Med Chem. 2008 Mar 13;51(5):1369-76. doi: 10.1021/jm070332f. Epub 2008 Feb 12. J Med Chem. 2008. PMID: 18266313 Free PMC article.

9

The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: hruby vj. J Med Chem. 2008 Oct 23;51(20):6334-47. doi: 10.1021/jm800389v. Epub 2008 Sep 27. J Med Chem. 2008. PMID: 18821747 Free PMC article.

10

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.

Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Yamamoto T, et al. Among authors: hruby vj. J Med Chem. 2009 Aug 27;52(16):5164-75. doi: 10.1021/jm900473p. J Med Chem. 2009. PMID: 20560643 Free PMC article.

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