Heifetz CL - Search Results

1

New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids.

Hagen SE, Domagala JM, Heifetz CL, Sanchez JP, Solomon M. Hagen SE, et al. Among authors: heifetz cl. J Med Chem. 1990 Feb;33(2):849-54. doi: 10.1021/jm00164a060. J Med Chem. 1990. PMID: 2153830

2

New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.

Sanchez JP, Bridges AJ, Bucsh R, Domagala JM, Gogliotti RD, Hagen SE, Heifetz CL, Joannides ET, Sesnie JC, Shapiro MA, et al. Sanchez JP, et al. Among authors: heifetz cl. J Med Chem. 1992 Jan 24;35(2):361-7. doi: 10.1021/jm00080a023. J Med Chem. 1992. PMID: 1732554

3

Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids.

Hagen SE, Domagala JM, Heifetz CL, Johnson J. Hagen SE, et al. Among authors: heifetz cl. J Med Chem. 1991 Mar;34(3):1155-61. doi: 10.1021/jm00107a040. J Med Chem. 1991. PMID: 2002456

4

In vitro antibacterial activities of PD 131628, a new 1,8-naphthyridine anti-infective agent.

Cohen MA, Huband MD, Mailloux GB, Yoder SL, Roland GE, Domagala JM, Heifetz CL. Cohen MA, et al. Among authors: heifetz cl. Antimicrob Agents Chemother. 1991 Jan;35(1):141-6. doi: 10.1128/AAC.35.1.141. Antimicrob Agents Chemother. 1991. PMID: 2014970 Free PMC article.

5

1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials.

Domagala JM, Heifetz CL, Hutt MP, Mich TF, Nichols JB, Solomon M, Worth DF. Domagala JM, et al. Among authors: heifetz cl. J Med Chem. 1988 May;31(5):991-1001. doi: 10.1021/jm00400a017. J Med Chem. 1988. PMID: 2834557

6

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay.

Domagala JM, Hanna LD, Heifetz CL, Hutt MP, Mich TF, Sanchez JP, Solomon M. Domagala JM, et al. Among authors: heifetz cl. J Med Chem. 1986 Mar;29(3):394-404. doi: 10.1021/jm00153a015. J Med Chem. 1986. PMID: 3005575

7

1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity.

Domagala JM, Heifetz CL, Mich TF, Nichols JB. Domagala JM, et al. Among authors: heifetz cl. J Med Chem. 1986 Apr;29(4):445-8. doi: 10.1021/jm00154a003. J Med Chem. 1986. PMID: 3007757 No abstract available.

8

7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.

Domagala JM, Hagen SE, Heifetz CL, Hutt MP, Mich TF, Sanchez JP, Trehan AK. Domagala JM, et al. Among authors: heifetz cl. J Med Chem. 1988 Mar;31(3):503-6. doi: 10.1021/jm00398a003. J Med Chem. 1988. PMID: 3346869 No abstract available.

9

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids.

Sanchez JP, Domagala JM, Hagen SE, Heifetz CL, Hutt MP, Nichols JB, Trehan AK. Sanchez JP, et al. Among authors: heifetz cl. J Med Chem. 1988 May;31(5):983-91. doi: 10.1021/jm00400a016. J Med Chem. 1988. PMID: 3361584

10

Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity.

Sanchez JP, Domagala JM, Heifetz CL, Priebe SR, Sesnie JA, Trehan AK. Sanchez JP, et al. Among authors: heifetz cl. J Med Chem. 1992 May 15;35(10):1764-73. doi: 10.1021/jm00088a011. J Med Chem. 1992. PMID: 1366133

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