Sanchez JP - Search Results

1

New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids.

Hagen SE, Domagala JM, Heifetz CL, Sanchez JP, Solomon M. Hagen SE, et al. Among authors: sanchez jp. J Med Chem. 1990 Feb;33(2):849-54. doi: 10.1021/jm00164a060. J Med Chem. 1990. PMID: 2153830

2

3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.

Ellsworth EL, Tran TP, Showalter HD, Sanchez JP, Watson BM, Stier MA, Domagala JM, Gracheck SJ, Joannides ET, Shapiro MA, Dunham SA, Hanna DL, Huband MD, Gage JW, Bronstein JC, Liu JY, Nguyen DQ, Singh R. Ellsworth EL, et al. Among authors: sanchez jp. J Med Chem. 2006 Nov 2;49(22):6435-8. doi: 10.1021/jm060505l. J Med Chem. 2006. PMID: 17064062

3

Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity.

Sanchez JP, Domagala JM, Heifetz CL, Priebe SR, Sesnie JA, Trehan AK. Sanchez JP, et al. J Med Chem. 1992 May 15;35(10):1764-73. doi: 10.1021/jm00088a011. J Med Chem. 1992. PMID: 1366133

4

New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.

Sanchez JP, Bridges AJ, Bucsh R, Domagala JM, Gogliotti RD, Hagen SE, Heifetz CL, Joannides ET, Sesnie JC, Shapiro MA, et al. Sanchez JP, et al. J Med Chem. 1992 Jan 24;35(2):361-7. doi: 10.1021/jm00080a023. J Med Chem. 1992. PMID: 1732554

5

Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.

Domagala JM, Bridges AJ, Culbertson TP, Gambino L, Hagen SE, Karrick G, Porter K, Sanchez JP, Sesnie JA, Spense FG, et al. Domagala JM, et al. Among authors: sanchez jp. J Med Chem. 1991 Mar;34(3):1142-54. doi: 10.1021/jm00107a039. J Med Chem. 1991. PMID: 1848296

6

5-Amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid (PD 124,816). Synthesis and biological evaluation of a new class of quinolone antibacterials.

Domagala JM, Hagen SE, Hutt MP, Sanchez JP, Sesnie J, Trehan AK. Domagala JM, et al. Among authors: sanchez jp. Drugs Exp Clin Res. 1988;14(7):453-60. Drugs Exp Clin Res. 1988. PMID: 2853667

7

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay.

Domagala JM, Hanna LD, Heifetz CL, Hutt MP, Mich TF, Sanchez JP, Solomon M. Domagala JM, et al. Among authors: sanchez jp. J Med Chem. 1986 Mar;29(3):394-404. doi: 10.1021/jm00153a015. J Med Chem. 1986. PMID: 3005575

8

7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.

Domagala JM, Hagen SE, Heifetz CL, Hutt MP, Mich TF, Sanchez JP, Trehan AK. Domagala JM, et al. Among authors: sanchez jp. J Med Chem. 1988 Mar;31(3):503-6. doi: 10.1021/jm00398a003. J Med Chem. 1988. PMID: 3346869 No abstract available.

9

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids.

Sanchez JP, Domagala JM, Hagen SE, Heifetz CL, Hutt MP, Nichols JB, Trehan AK. Sanchez JP, et al. J Med Chem. 1988 May;31(5):983-91. doi: 10.1021/jm00400a016. J Med Chem. 1988. PMID: 3361584

10

The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents.

Sanchez JP, Gogliotti RD, Domagala JM, Gracheck SJ, Huband MD, Sesnie JA, Cohen MA, Shapiro MA. Sanchez JP, et al. J Med Chem. 1995 Oct 27;38(22):4478-87. doi: 10.1021/jm00022a013. J Med Chem. 1995. PMID: 7473575

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