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Page 1
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sánchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E. Hebeisen P, et al. Among authors: kirchner s. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3237-42. doi: 10.1016/j.bmcl.2011.04.044. Epub 2011 Apr 20. Bioorg Med Chem Lett. 2011. PMID: 21550236
Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
Liu Y, Wu J, Zhou M, Chen W, Li D, Wang Z, Hornsperger B, Aebi JD, Märki HP, Kuhn B, Wang L, Kuglstatter A, Benz J, Müller S, Hochstrasser R, Ottaviani G, Xin J, Kirchner S, Mohr S, Verry P, Riboulet W, Shen HC, Mayweg AV, Amrein K, Tan X. Liu Y, et al. Among authors: kirchner s. J Med Chem. 2020 Jul 9;63(13):6876-6897. doi: 10.1021/acs.jmedchem.0c00233. Epub 2020 Jun 25. J Med Chem. 2020. PMID: 32530624
Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.
Lucas MC, Bhagirath N, Chiao E, Goldstein DM, Hermann JC, Hsu PY, Kirchner S, Kennedy-Smith JJ, Kuglstatter A, Lukacs C, Menke J, Niu L, Padilla F, Peng Y, Polonchuk L, Railkar A, Slade M, Soth M, Xu D, Yadava P, Yee C, Zhou M, Liao C. Lucas MC, et al. Among authors: kirchner s. J Med Chem. 2014 Mar 27;57(6):2683-91. doi: 10.1021/jm401982j. Epub 2014 Feb 26. J Med Chem. 2014. PMID: 24520947
Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy.
Ratni H, Karp GM, Weetall M, Naryshkin NA, Paushkin SV, Chen KS, McCarthy KD, Qi H, Turpoff A, Woll MG, Zhang X, Zhang N, Yang T, Dakka A, Vazirani P, Zhao X, Pinard E, Green L, David-Pierson P, Tuerck D, Poirier A, Muster W, Kirchner S, Mueller L, Gerlach I, Metzger F. Ratni H, et al. Among authors: kirchner s. J Med Chem. 2016 Jul 14;59(13):6086-100. doi: 10.1021/acs.jmedchem.6b00459. Epub 2016 Jul 6. J Med Chem. 2016. PMID: 27299419
The photomutagenicity of fluoroquinolones and other drugs.
Gocke E, Albertini S, Chételat AA, Kirchner S, Muster W. Gocke E, et al. Among authors: kirchner s. Toxicol Lett. 1998 Dec 28;102-103:375-81. doi: 10.1016/s0378-4274(98)00235-5. Toxicol Lett. 1998. PMID: 10022282 Review.
Computational toxicology in drug development.
Muster W, Breidenbach A, Fischer H, Kirchner S, Müller L, Pähler A. Muster W, et al. Among authors: kirchner s. Drug Discov Today. 2008 Apr;13(7-8):303-10. doi: 10.1016/j.drudis.2007.12.007. Epub 2008 Feb 20. Drug Discov Today. 2008. PMID: 18405842 Review.
Phototoxicity and photogenotoxicity of nine pyridone derivatives.
Gocke E, Chételat AA, Csato M, McGarvey DJ, Jakob-Roetne R, Kirchner S, Muster W, Potthast M, Widmer U. Gocke E, et al. Among authors: kirchner s. Mutat Res. 2003 Feb 5;535(1):43-54. doi: 10.1016/s1383-5718(02)00283-8. Mutat Res. 2003. PMID: 12547282
268 results