Lipinski CA - Search Results

1

A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate.

Chenard BL, Lipinski CA, Dominy BW, Mena EE, Ronau RT, Butterfield GC, Marinovic LC, Pagnozzi M, Butler TW, Tsang T. Chenard BL, et al. Among authors: lipinski ca. J Med Chem. 1990 Mar;33(3):1077-83. doi: 10.1021/jm00165a030. J Med Chem. 1990. PMID: 2155321

2

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Lipinski CA, et al. Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26. doi: 10.1016/s0169-409x(00)00129-0. Adv Drug Deliv Rev. 2001. PMID: 11259830 Review.

3

Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.

Lipinski CA, Aldinger CE, Beyer TA, Bordner J, Burdi DF, Bussolotti DL, Inskeep PB, Siegel TW. Lipinski CA, et al. J Med Chem. 1992 Jun 12;35(12):2169-77. doi: 10.1021/jm00090a004. J Med Chem. 1992. PMID: 1613744

4

Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida.

McFarland JW, Berger CM, Froshauer SA, Hayashi SF, Hecker SJ, Jaynes BH, Jefson MR, Kamicker BJ, Lipinski CA, Lundy KM, Reese CP, Vu CB. McFarland JW, et al. Among authors: lipinski ca. J Med Chem. 1997 Apr 25;40(9):1340-6. doi: 10.1021/jm960436i. J Med Chem. 1997. PMID: 9135031

5

Medicinal chemistry of aldose reductase inhibitors.

Larson ER, Lipinski CA, Sarges R. Larson ER, et al. Among authors: lipinski ca. Med Res Rev. 1988 Apr-Jun;8(2):159-86. doi: 10.1002/med.2610080202. Med Res Rev. 1988. PMID: 3132580 Review. No abstract available.

6

Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists.

Lipinski CA, LaMattina JL, Oates PJ. Lipinski CA, et al. J Med Chem. 1986 Nov;29(11):2154-63. doi: 10.1021/jm00161a005. J Med Chem. 1986. PMID: 2878075

7

Pseudosymmetry and bioisosterism in biaryl pyridyl competitive histamine H2-receptor antagonists.

Lipinski CA, LaMattina JL, Hohnke LA. Lipinski CA, et al. J Med Chem. 1985 Nov;28(11):1628-36. doi: 10.1021/jm00149a015. J Med Chem. 1985. PMID: 2866245

8

Bioisosteric design of conformationally restricted pyridyltriazole histamine H2-receptor antagonists.

Lipinski CA. Lipinski CA. J Med Chem. 1983 Jan;26(1):1-6. doi: 10.1021/jm00355a001. J Med Chem. 1983. PMID: 6131126

9

Parallel worlds of public and commercial bioactive chemistry data.

Lipinski CA, Litterman NK, Southan C, Williams AJ, Clark AM, Ekins S. Lipinski CA, et al. J Med Chem. 2015 Mar 12;58(5):2068-76. doi: 10.1021/jm5011308. Epub 2014 Dec 4. J Med Chem. 2015. PMID: 25415348 Free PMC article.

10

Bronchodilator and antiulcer phenoxypyrimidinones.

Lipinski CA, Stam JG, Pereira JN, Ackerman NR, Hess HJ. Lipinski CA, et al. J Med Chem. 1980 Sep;23(9):1026-31. doi: 10.1021/jm00183a012. J Med Chem. 1980. PMID: 7411545

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