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Page 1
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM. Mulligan P, et al. Among authors: toiber d. Mol Cell. 2011 Jun 10;42(5):689-99. doi: 10.1016/j.molcel.2011.04.020. Epub 2011 May 19. Mol Cell. 2011. PMID: 21596603 Free PMC article.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. Zhong L, et al. Among authors: d urso a, toiber d. Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041. Cell. 2010. PMID: 20141841 Free PMC article.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. Sebastián C, et al. Among authors: toiber d. Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047. Cell. 2012. PMID: 23217706 Free PMC article.
SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.
Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R. Toiber D, et al. Among authors: d urso a. Mol Cell. 2013 Aug 22;51(4):454-68. doi: 10.1016/j.molcel.2013.06.018. Epub 2013 Aug 1. Mol Cell. 2013. PMID: 23911928 Free PMC article.
Neuroprotective Functions for the Histone Deacetylase SIRT6.
Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D. Kaluski S, et al. Among authors: toiber d. Cell Rep. 2017 Mar 28;18(13):3052-3062. doi: 10.1016/j.celrep.2017.03.008. Cell Rep. 2017. PMID: 28355558 Free PMC article.
TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.
Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM. Lobbardi R, et al. Among authors: toiber d. Cancer Discov. 2017 Nov;7(11):1336-1353. doi: 10.1158/2159-8290.CD-17-0267. Epub 2017 Oct 3. Cancer Discov. 2017. PMID: 28974511 Free PMC article.
SIRT6 is a key regulator of mitochondrial function in the brain.
Smirnov D, Eremenko E, Stein D, Kaluski S, Jasinska W, Cosentino C, Martinez-Pastor B, Brotman Y, Mostoslavsky R, Khrameeva E, Toiber D. Smirnov D, et al. Among authors: toiber d. Cell Death Dis. 2023 Jan 18;14(1):35. doi: 10.1038/s41419-022-05542-w. Cell Death Dis. 2023. PMID: 36653345 Free PMC article.
40 results