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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF. Samuel MS, et al. Among authors: olson mf. Cancer Cell. 2011 Jun 14;19(6):776-91. doi: 10.1016/j.ccr.2011.05.008. Cancer Cell. 2011. PMID: 21665151 Free PMC article.
AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.
Spence HJ, McGarry L, Chew CS, Carragher NO, Scott-Carragher LA, Yuan Z, Croft DR, Olson MF, Frame M, Ozanne BW. Spence HJ, et al. Among authors: olson mf. Mol Cell Biol. 2006 Feb;26(4):1480-95. doi: 10.1128/MCB.26.4.1480-1495.2006. Mol Cell Biol. 2006. PMID: 16449658 Free PMC article.
Applications for ROCK kinase inhibition.
Olson MF. Olson MF. Curr Opin Cell Biol. 2008 Apr;20(2):242-8. doi: 10.1016/j.ceb.2008.01.002. Epub 2008 Feb 20. Curr Opin Cell Biol. 2008. PMID: 18282695 Free PMC article. Review.
135 results