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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF. Samuel MS, et al. Among authors: timpson p. Cancer Cell. 2011 Jun 14;19(6):776-91. doi: 10.1016/j.ccr.2011.05.008. Cancer Cell. 2011. PMID: 21665151 Free PMC article.
Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma.
Hastings JF, Latham SL, Kamili A, Wheatley MS, Han JZR, Wong-Erasmus M, Phimmachanh M, Nobis M, Pantarelli C, Cadell AL, O'Donnell YEI, Leong KH, Lynn S, Geng FS, Cui L, Yan S, Achinger-Kawecka J, Stirzaker C, Norris MD, Haber M, Trahair TN, Speleman F, De Preter K, Cowley MJ, Bogdanovic O, Timpson P, Cox TR, Kolch W, Fletcher JI, Fey D, Croucher DR. Hastings JF, et al. Among authors: timpson p. Sci Adv. 2023 Mar 3;9(9):eabp8314. doi: 10.1126/sciadv.abp8314. Epub 2023 Mar 3. Sci Adv. 2023. PMID: 36867694 Free PMC article.
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. Boslem E, et al. Among authors: timpson p. Sci Adv. 2023 Sep 15;9(37):eadh0831. doi: 10.1126/sciadv.adh0831. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703359 Free PMC article.
Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone.
Bhattacharyya ND, Kyaw W, McDonald MM, Dhenni R, Grootveld AK, Xiao Y, Chai R, Khoo WH, Danserau LC, Sergio CM, Timpson P, Lee WM, Croucher PI, Phan TG. Bhattacharyya ND, et al. Among authors: timpson p. Nat Protoc. 2023 Dec;18(12):3856-3880. doi: 10.1038/s41596-023-00894-9. Epub 2023 Oct 19. Nat Protoc. 2023. PMID: 37857852 Review.
Multiphoton intravital microscopy of rodents.
Scheele CLGJ, Herrmann D, Yamashita E, Celso CL, Jenne CN, Oktay MH, Entenberg D, Friedl P, Weigert R, Meijboom FLB, Ishii M, Timpson P, van Rheenen J. Scheele CLGJ, et al. Among authors: timpson p. Nat Rev Methods Primers. 2022;2:89. doi: 10.1038/s43586-022-00168-w. Epub 2022 Nov 10. Nat Rev Methods Primers. 2022. PMID: 37621948 Free PMC article.
146 results