Ram PT - Search Results

1

Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling.

Lu Y, Muller M, Smith D, Dutta B, Komurov K, Iadevaia S, Ruths D, Tseng JT, Yu S, Yu Q, Nakhleh L, Balazsi G, Donnelly J, Schurdak M, Morgan-Lappe S, Fesik S, Ram PT, Mills GB. Lu Y, et al. Among authors: ram pt. Oncogene. 2011 Nov 10;30(45):4567-77. doi: 10.1038/onc.2011.164. Epub 2011 Jun 13. Oncogene. 2011. PMID: 21666717 Free PMC article.

2

Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis.

Iadevaia S, Lu Y, Morales FC, Mills GB, Ram PT. Iadevaia S, et al. Among authors: ram pt. Cancer Res. 2010 Sep 1;70(17):6704-14. doi: 10.1158/0008-5472.CAN-10-0460. Epub 2010 Jul 19. Cancer Res. 2010. PMID: 20643779 Free PMC article.

3

Exploiting the PI3K/AKT pathway for cancer drug discovery.

Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Hennessy BT, et al. Among authors: ram pt. Nat Rev Drug Discov. 2005 Dec;4(12):988-1004. doi: 10.1038/nrd1902. Nat Rev Drug Discov. 2005. PMID: 16341064 Review.

4

Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.

Muller M, Obeyesekere M, Mills GB, Ram PT. Muller M, et al. Among authors: ram pt. FASEB J. 2008 May;22(5):1393-403. doi: 10.1096/fj.07-9100com. Epub 2008 Jan 2. FASEB J. 2008. PMID: 18171696

5

The signaling petri net-based simulator: a non-parametric strategy for characterizing the dynamics of cell-specific signaling networks.

Ruths D, Muller M, Tseng JT, Nakhleh L, Ram PT. Ruths D, et al. Among authors: ram pt. PLoS Comput Biol. 2008 Feb 29;4(2):e1000005. doi: 10.1371/journal.pcbi.1000005. PLoS Comput Biol. 2008. PMID: 18463702 Free PMC article.

6

Patterns of human gene expression variance show strong associations with signaling network hierarchy.

Komurov K, Ram PT. Komurov K, et al. Among authors: ram pt. BMC Syst Biol. 2010 Nov 12;4:154. doi: 10.1186/1752-0509-4-154. BMC Syst Biol. 2010. PMID: 21073694 Free PMC article.

7

Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.

Seviour EG, Sehgal V, Lu Y, Luo Z, Moss T, Zhang F, Hill SM, Liu W, Maiti SN, Cooper L, Azencot R, Lopez-Berestein G, Rodriguez-Aguayo C, Roopaimoole R, Pecot CV, Sood AK, Mukherjee S, Gray JW, Mills GB, Ram PT. Seviour EG, et al. Among authors: ram pt. Oncogene. 2016 Feb 11;35(6):691-701. doi: 10.1038/onc.2014.469. Epub 2015 Feb 2. Oncogene. 2016. PMID: 25639871 Free PMC article.

8

Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p.

Seviour EG, Sehgal V, Mishra D, Rupaimoole R, Rodriguez-Aguayo C, Lopez-Berestein G, Lee JS, Sood AK, Kim MP, Mills GB, Ram PT. Seviour EG, et al. Among authors: ram pt. Oncogene. 2017 Mar;36(10):1339-1350. doi: 10.1038/onc.2016.308. Epub 2016 Sep 26. Oncogene. 2017. PMID: 27669434 Free PMC article.

9

Mapping network motif tunability and robustness in the design of synthetic signaling circuits.

Iadevaia S, Nakhleh LK, Azencott R, Ram PT. Iadevaia S, et al. Among authors: ram pt. PLoS One. 2014 Mar 18;9(3):e91743. doi: 10.1371/journal.pone.0091743. eCollection 2014. PLoS One. 2014. PMID: 24642504 Free PMC article.

10

Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells.

Gopal YN, Deng W, Woodman SE, Komurov K, Ram P, Smith PD, Davies MA. Gopal YN, et al. Cancer Res. 2010 Nov 1;70(21):8736-47. doi: 10.1158/0008-5472.CAN-10-0902. Epub 2010 Oct 19. Cancer Res. 2010. PMID: 20959481 Free PMC article.

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