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Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.
Schoenwaelder SM, Jarman KE, Gardiner EE, Hua M, Qiao J, White MJ, Josefsson EC, Alwis I, Ono A, Willcox A, Andrews RK, Mason KD, Salem HH, Huang DC, Kile BT, Roberts AW, Jackson SP. Schoenwaelder SM, et al. Among authors: salem hh. Blood. 2011 Aug 11;118(6):1663-74. doi: 10.1182/blood-2011-04-347849. Epub 2011 Jun 14. Blood. 2011. PMID: 21673344 Free article.
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.
Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP. Schoenwaelder SM, et al. Among authors: salem hh. Blood. 2009 Jul 16;114(3):663-6. doi: 10.1182/blood-2009-01-200345. Epub 2009 Apr 22. Blood. 2009. PMID: 19387006 Free article.
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.
Schoenwaelder SM, Hughan SC, Boniface K, Fernando S, Holdsworth M, Thompson PE, Salem HH, Jackson SP. Schoenwaelder SM, et al. Among authors: salem hh. J Biol Chem. 2002 Apr 26;277(17):14738-46. doi: 10.1074/jbc.M200661200. Epub 2002 Feb 5. J Biol Chem. 2002. PMID: 11830597 Free article.
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.
Schoenwaelder SM, Ono A, Sturgeon S, Chan SM, Mangin P, Maxwell MJ, Turnbull S, Mulchandani M, Anderson K, Kauffenstein G, Rewcastle GW, Kendall J, Gachet C, Salem HH, Jackson SP. Schoenwaelder SM, et al. Among authors: salem hh. J Biol Chem. 2007 Sep 28;282(39):28648-28658. doi: 10.1074/jbc.M704358200. Epub 2007 Aug 2. J Biol Chem. 2007. PMID: 17673465 Free article.
162 results