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Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.
Chen H, Blizzard TA, Kim S, Wu J, Young K, Park YW, Ogawa AM, Raghoobar S, Painter RE, Wisniewski D, Hairston N, Fitzgerald P, Sharma N, Scapin G, Lu J, Hermes J, Hammond ML. Chen H, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4267-70. doi: 10.1016/j.bmcl.2011.05.065. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21676616
Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.
Chen HY, Kim S, Wu JY, Birzin ET, Chan W, Yang YT, Dahllund J, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML. Chen HY, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2004 May 17;14(10):2551-4. doi: 10.1016/j.bmcl.2004.02.084. Bioorg Med Chem Lett. 2004. PMID: 15109649
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.
Blizzard TA, DiNinno F, Morgan JD 2nd, Chen HY, Wu JY, Gude C, Kim S, Chan W, Birzin ET, Tien Yang Y, Pai LY, Zhang Z, Hayes EC, DaSilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML. Blizzard TA, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3861-4. doi: 10.1016/j.bmcl.2004.05.074. Bioorg Med Chem Lett. 2004. PMID: 15225685
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML. Blizzard TA, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. doi: 10.1016/j.bmcl.2004.10.036. Bioorg Med Chem Lett. 2005. PMID: 15582421
Androstenediol analogs as ER-beta-selective SERMs.
Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Sharma N, Fitzgerald PM, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. doi: 10.1016/j.bmcl.2005.11.014. Epub 2005 Nov 23. Bioorg Med Chem Lett. 2006. PMID: 16309907
Bridged androstenediol analogs as ER-beta selective SERMs.
Blizzard TA, Gude C, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Holmes MA, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2007 May 15;17(10):2944-8. doi: 10.1016/j.bmcl.2006.12.053. Epub 2006 Dec 21. Bioorg Med Chem Lett. 2007. PMID: 17448656
Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.
Blizzard TA, Chen H, Kim S, Wu J, Young K, Park YW, Ogawa A, Raghoobar S, Painter RE, Hairston N, Lee SH, Misura A, Felcetto T, Fitzgerald P, Sharma N, Lu J, Ha S, Hickey E, Hermes J, Hammond ML. Blizzard TA, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2010 Feb 1;20(3):918-21. doi: 10.1016/j.bmcl.2009.12.069. Epub 2009 Dec 23. Bioorg Med Chem Lett. 2010. PMID: 20044254
Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.
Tan Q, Ogawa AM, Raghoobar SL, Wisniewski D, Colwell L, Park YW, Young K, Hermes JD, Dininno FP, Hammond ML. Tan Q, et al. Among authors: hammond ml. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4363-5. doi: 10.1016/j.bmcl.2011.04.122. Epub 2011 May 13. Bioorg Med Chem Lett. 2011. PMID: 21664132
99 results