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Methotrexate chronotherapy is effective against rheumatoid arthritis.
To H, Yoshimatsu H, Tomonari M, Ida H, Tsurumoto T, Tsuji Y, Sonemoto E, Shimasaki N, Koyanagi S, Sasaki H, Ieiri I, Higuchi S, Kawakami A, Ueki Y, Eguchi K. To H, et al. Among authors: yoshimatsu h. Chronobiol Int. 2011 Apr;28(3):267-74. doi: 10.3109/07420528.2011.553017. Chronobiol Int. 2011. PMID: 21452922 Clinical Trial.
Application of model-informed drug development (MIDD) for dose selection in regulatory submissions for drug approval in Japan.
JPMA MIDD Task force; Sasaki T, Katsube T, Hayato S, Yamaguchi S, Tanaka J, Yoshimatsu H, Nakanishi Y, Kitamura A, Watase H, Suganami H, Matsuoka N, Hasegawa C. JPMA MIDD Task force, et al. Among authors: yoshimatsu h. J Pharmacokinet Pharmacodyn. 2025 Jan 6;52(1):10. doi: 10.1007/s10928-024-09954-3. J Pharmacokinet Pharmacodyn. 2025. PMID: 39762622
646 results