Letai AG - Search Results

1

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance.

Barbone D, Ryan JA, Kolhatkar N, Chacko AD, Jablons DM, Sugarbaker DJ, Bueno R, Letai AG, Coussens LM, Fennell DA, Broaddus VC. Barbone D, et al. Among authors: letai ag. Cell Death Dis. 2011 Jun 23;2(6):e174. doi: 10.1038/cddis.2011.58. Cell Death Dis. 2011. PMID: 21697949 Free PMC article.

2

Bcl-xL controls a switch between cell death modes during mitotic arrest.

Bah N, Maillet L, Ryan J, Dubreil S, Gautier F, Letai A, Juin P, Barillé-Nion S. Bah N, et al. Cell Death Dis. 2014 Jun 12;5(6):e1291. doi: 10.1038/cddis.2014.251. Cell Death Dis. 2014. PMID: 24922075 Free PMC article.

3

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.

Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, Stewart RA, Langenau DM, Look AT, Letai A. Jette CA, et al. Cell Death Differ. 2008 Jun;15(6):1063-72. doi: 10.1038/cdd.2008.42. Epub 2008 Apr 11. Cell Death Differ. 2008. PMID: 18404156 Free PMC article.

4

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL.

Le Pen J, Maillet L, Sarosiek K, Vuillier C, Gautier F, Montessuit S, Martinou JC, Letaï A, Braun F, Juin PP. Le Pen J, et al. Cell Death Dis. 2016 Feb 4;7(2):e2083. doi: 10.1038/cddis.2015.400. Cell Death Dis. 2016. PMID: 26844698 Free PMC article.

5

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.

Touzeau C, Ryan J, Guerriero J, Moreau P, Chonghaile TN, Le Gouill S, Richardson P, Anderson K, Amiot M, Letai A. Touzeau C, et al. Leukemia. 2016 Mar;30(3):761-4. doi: 10.1038/leu.2015.184. Epub 2015 Jul 15. Leukemia. 2016. PMID: 26174630 Free PMC article. No abstract available.

6

Why do BCL-2 inhibitors work and where should we use them in the clinic?

Montero J, Letai A. Montero J, et al. Cell Death Differ. 2018 Jan;25(1):56-64. doi: 10.1038/cdd.2017.183. Epub 2017 Oct 27. Cell Death Differ. 2018. PMID: 29077093 Free PMC article. Review.

7

Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells.

Colak S, Zimberlin CD, Fessler E, Hogdal L, Prasetyanti PR, Grandela CM, Letai A, Medema JP. Colak S, et al. Cell Death Differ. 2014 Jul;21(7):1170-7. doi: 10.1038/cdd.2014.37. Epub 2014 Mar 28. Cell Death Differ. 2014. PMID: 24682005 Free PMC article.

8

Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis.

Gunda V, Sarosiek KA, Brauner E, Kim YS, Amin S, Zhou Z, Letai A, Parangi S. Gunda V, et al. Cancer Lett. 2017 Jun 1;395:1-10. doi: 10.1016/j.canlet.2017.02.028. Epub 2017 Mar 1. Cancer Lett. 2017. PMID: 28259821

9

p53 regulates a non-apoptotic death induced by ROS.

Montero J, Dutta C, van Bodegom D, Weinstock D, Letai A. Montero J, et al. Cell Death Differ. 2013 Nov;20(11):1465-74. doi: 10.1038/cdd.2013.52. Epub 2013 May 24. Cell Death Differ. 2013. PMID: 23703322 Free PMC article.

10

BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2.

Flanagan AM, Letai A. Flanagan AM, et al. Cell Death Differ. 2008 Mar;15(3):580-8. doi: 10.1038/sj.cdd.4402292. Epub 2007 Dec 14. Cell Death Differ. 2008. PMID: 18084238 Free PMC article.

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