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A comparative study of fragment screening methods on the p38α kinase: new methods, new insights.
Pollack SJ, Beyer KS, Lock C, Müller I, Sheppard D, Lipkin M, Hardick D, Blurton P, Leonard PM, Hubbard PA, Todd D, Richardson CM, Ahrens T, Baader M, Hafenbradl DO, Hilyard K, Bürli RW. Pollack SJ, et al. Among authors: sheppard d. J Comput Aided Mol Des. 2011 Jul;25(7):677-87. doi: 10.1007/s10822-011-9454-9. Epub 2011 Jul 6. J Comput Aided Mol Des. 2011. PMID: 21732248 Free PMC article.
The design and application of target-focused compound libraries.
Harris CJ, Hill RD, Sheppard DW, Slater MJ, Stouten PF. Harris CJ, et al. Among authors: sheppard dw. Comb Chem High Throughput Screen. 2011 Jul;14(6):521-31. doi: 10.2174/138620711795767802. Comb Chem High Throughput Screen. 2011. PMID: 21521154 Free PMC article.
Strategies for small molecule library design.
Sheppard DW, Lipkin MJ, Harris CJ, Catana C, Stouten PF. Sheppard DW, et al. Curr Pharm Des. 2014;20(20):3314-22. doi: 10.2174/13816128113199990602. Curr Pharm Des. 2014. PMID: 23947648 Review.
Building in molecular diversity for targeted libraries.
Sheppard DW, MacRitchie JA. Sheppard DW, et al. Drug Discov Today Technol. 2013 Dec;10(4):e461-6. doi: 10.1016/j.ddtec.2012.12.002. Drug Discov Today Technol. 2013. PMID: 24451635 Review.
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).
Martínez-Botella G, Breen JN, Duffy JE, Dumas J, Geng B, Gowers IK, Green OM, Guler S, Hentemann MF, Hernandez-Juan FA, Joseph-McCarthy D, Kawatkar S, Larsen NA, Lazari O, Loch JT, Macritchie JA, McKenzie AR, Newman JV, Olivier NB, Otterson LG, Owens AP, Read J, Sheppard DW, Keating TA. Martínez-Botella G, et al. Among authors: sheppard dw. J Med Chem. 2012 Nov 26;55(22):10010-21. doi: 10.1021/jm3011806. Epub 2012 Oct 24. J Med Chem. 2012. PMID: 23043329
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ, Sheppard DW, Russell AJ, Hammond EM, Knapp S, Brennan PE, Conway SJ. Hewings DS, et al. J Med Chem. 2013 Apr 25;56(8):3217-27. doi: 10.1021/jm301588r. Epub 2013 Apr 5. J Med Chem. 2013. PMID: 23517011 Free PMC article.
918 results