Watterson DM - Search Results

1

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).

Bachstetter AD, Xing B, de Almeida L, Dimayuga ER, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neuroinflammation. 2011 Jul 6;8:79. doi: 10.1186/1742-2094-8-79. J Neuroinflammation. 2011. PMID: 21733175 Free PMC article.

2

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ, Watterson DM. Munoz L, et al. Among authors: watterson dm. J Neuroinflammation. 2007 Sep 4;4:21. doi: 10.1186/1742-2094-4-21. J Neuroinflammation. 2007. PMID: 17784957 Free PMC article.

3

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.

Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS. Lloyd E, et al. Among authors: watterson dm. J Neuroinflammation. 2008 Jun 30;5:28. doi: 10.1186/1742-2094-5-28. J Neuroinflammation. 2008. PMID: 18590543 Free PMC article.

4

Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.

Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neurosci. 2012 Jul 25;32(30):10201-10. doi: 10.1523/JNEUROSCI.1496-12.2012. J Neurosci. 2012. PMID: 22836255 Free PMC article.

5

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

Bachstetter AD, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60. doi: 10.1007/s11481-014-9543-3. Epub 2014 May 1. J Neuroimmune Pharmacol. 2014. PMID: 24789302 Free PMC article.

6

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.

Bachstetter AD, Webster SJ, Goulding DS, Morton JE, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neuroinflammation. 2015 Apr 10;12:69. doi: 10.1186/s12974-015-0289-5. J Neuroinflammation. 2015. PMID: 25886256 Free PMC article.

7

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.

Bachstetter AD, Zhou Z, Rowe RK, Xing B, Goulding DS, Conley AN, Sompol P, Meier S, Abisambra JF, Lifshitz J, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. PLoS One. 2016 Feb 12;11(2):e0149451. doi: 10.1371/journal.pone.0149451. eCollection 2016. PLoS One. 2016. PMID: 26871438 Free PMC article.

8

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.

Zhou Z, Bachstetter AD, Späni CB, Roy SM, Watterson DM, Van Eldik LJ. Zhou Z, et al. Among authors: watterson dm. J Neuroinflammation. 2017 Apr 5;14(1):75. doi: 10.1186/s12974-017-0845-2. J Neuroinflammation. 2017. PMID: 28381303 Free PMC article.

9

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid.

Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Craft JM, et al. Among authors: watterson dm. J Neuroinflammation. 2005 Jun 20;2:15. doi: 10.1186/1742-2094-2-15. J Neuroinflammation. 2005. PMID: 15967035 Free PMC article.

10

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration.

Craft JM, Watterson DM, Van Eldik LJ. Craft JM, et al. Among authors: watterson dm. Glia. 2006 Apr 1;53(5):484-90. doi: 10.1002/glia.20306. Glia. 2006. PMID: 16369931

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