Nieland TJ - Search Results

1

Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity.

Yu M, Romer KA, Nieland TJ, Xu S, Saenz-Vash V, Penman M, Yesilaltay A, Carr SA, Krieger M. Yu M, et al. Among authors: nieland tj. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12243-8. doi: 10.1073/pnas.1109078108. Epub 2011 Jul 11. Proc Natl Acad Sci U S A. 2011. PMID: 21746906 Free PMC article.

2

Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI.

Nieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T. Nieland TJ, et al. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7. doi: 10.1073/pnas.222421399. Epub 2002 Nov 18. Proc Natl Acad Sci U S A. 2002. PMID: 12438696 Free PMC article.

3

Negatively cooperative binding of high-density lipoprotein to the HDL receptor SR-BI.

Nieland TJ, Xu S, Penman M, Krieger M. Nieland TJ, et al. Biochemistry. 2011 Mar 22;50(11):1818-30. doi: 10.1021/bi101657j. Epub 2011 Feb 25. Biochemistry. 2011. PMID: 21254782 Free PMC article.

4

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide.

Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M. Nieland TJ, et al. J Lipid Res. 2004 Jul;45(7):1256-65. doi: 10.1194/jlr.M300358-JLR200. Epub 2004 Apr 21. J Lipid Res. 2004. PMID: 15102890 Free article.

5

Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI.

Nieland TJ, Ehrlich M, Krieger M, Kirchhausen T. Nieland TJ, et al. Biochim Biophys Acta. 2005 May 1;1734(1):44-51. doi: 10.1016/j.bbalip.2005.02.007. Epub 2005 Mar 9. Biochim Biophys Acta. 2005. PMID: 15866482

6

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.

Chroni A, Nieland TJ, Kypreos KE, Krieger M, Zannis VI. Chroni A, et al. Among authors: nieland tj. Biochemistry. 2005 Oct 4;44(39):13132-43. doi: 10.1021/bi051029o. Biochemistry. 2005. PMID: 16185081

7

Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.

Nieland TJ, Shaw JT, Jaipuri FA, Maliga Z, Duffner JL, Koehler AN, Krieger M. Nieland TJ, et al. J Lipid Res. 2007 Aug;48(8):1832-45. doi: 10.1194/jlr.M700209-JLR200. Epub 2007 May 28. J Lipid Res. 2007. PMID: 17533223 Free article.

8

Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.

Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M. Nieland TJ, et al. Biochemistry. 2008 Jan 8;47(1):460-72. doi: 10.1021/bi701277x. Epub 2007 Dec 8. Biochemistry. 2008. PMID: 18067275 Free PMC article.

9

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Dockendorff C, Faloon PW, Pu J, Yu M, Johnston S, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M. Dockendorff C, et al. Among authors: nieland tj. Bioorg Med Chem Lett. 2015;25(10):2100-5. doi: 10.1016/j.bmcl.2015.03.073. Epub 2015 Apr 1. Bioorg Med Chem Lett. 2015. PMID: 25900219 Free PMC article.

10

Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Dockendorff C, Faloon PW, Germain A, Yu M, Youngsaye W, Nag PP, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M. Dockendorff C, et al. Among authors: nieland tj. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2594-8. doi: 10.1016/j.bmcl.2015.03.074. Epub 2015 Apr 11. Bioorg Med Chem Lett. 2015. PMID: 25958245 Free PMC article.

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