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Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.
Li X, Chan TO, Myers V, Chowdhury I, Zhang XQ, Song J, Zhang J, Andrel J, Funakoshi H, Robbins J, Koch WJ, Hyslop T, Cheung JY, Feldman AM. Li X, et al. Among authors: chan to. Circulation. 2011 Aug 2;124(5):572-81. doi: 10.1161/CIRCULATIONAHA.111.021352. Epub 2011 Jul 11. Circulation. 2011. PMID: 21747049 Free PMC article.
Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger.
Song J, Gao E, Wang J, Zhang XQ, Chan TO, Koch WJ, Shang X, Joseph JI, Peterson BZ, Feldman AM, Cheung JY. Song J, et al. Among authors: chan to. Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H770-81. doi: 10.1152/ajpheart.00733.2011. Epub 2011 Nov 11. Am J Physiol Heart Circ Physiol. 2012. PMID: 22081699 Free PMC article.
Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.
Funakoshi H, Chan TO, Good JC, Libonati JR, Piuhola J, Chen X, MacDonnell SM, Lee LL, Herrmann DE, Zhang J, Martini J, Palmer TM, Sanbe A, Robbins J, Houser SR, Koch WJ, Feldman AM. Funakoshi H, et al. Among authors: chan to. Circulation. 2006 Nov 21;114(21):2240-50. doi: 10.1161/CIRCULATIONAHA.106.620211. Epub 2006 Nov 6. Circulation. 2006. PMID: 17088462
Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor.
Chan TO, Funakoshi H, Song J, Zhang XQ, Wang J, Chung PH, DeGeorge BR Jr, Li X, Zhang J, Herrmann DE, Diamond M, Hamad E, Houser SR, Koch WJ, Cheung JY, Feldman AM. Chan TO, et al. Clin Transl Sci. 2008 Sep;1(2):126-33. doi: 10.1111/j.1752-8062.2008.00027.x. Clin Transl Sci. 2008. PMID: 20354569 Free PMC article.
Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity.
Hamad EA, Li X, Song J, Zhang XQ, Myers V, Funakoshi H, Zhang J, Wang J, Li J, Swope D, Madonick A, Farber J, Radice GL, Cheung JY, Chan TO, Feldman AM. Hamad EA, et al. Among authors: chan to. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1738-47. doi: 10.1152/ajpheart.00688.2009. Epub 2010 Apr 2. Am J Physiol Heart Circ Physiol. 2010. PMID: 20363887 Free PMC article.
Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3.
Feiner EC, Chung P, Jasmin JF, Zhang J, Whitaker-Menezes D, Myers V, Song J, Feldman EW, Funakoshi H, Degeorge BR Jr, Yelamarty RV, Koch WJ, Lisanti MP, McTiernan CF, Cheung JY, Bristow MR, Chan TO, Feldman AM. Feiner EC, et al. Among authors: chan to. J Card Fail. 2011 Mar;17(3):253-63. doi: 10.1016/j.cardfail.2010.10.008. Epub 2010 Dec 24. J Card Fail. 2011. PMID: 21362533 Free PMC article.
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