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Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Marx CE, Keefe RS, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, Strauss JL, Naylor JC, Payne VM, Lieberman JA, Savitz AJ, Leimone LA, Dunn L, Porcu P, Morrow AL, Shampine LJ. Marx CE, et al. Among authors: strauss jl. Neuropsychopharmacology. 2009 Jul;34(8):1885-903. doi: 10.1038/npp.2009.26. Epub 2009 Apr 1. Neuropsychopharmacology. 2009. PMID: 19339966 Free PMC article. Clinical Trial.
Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.
Naylor JC, Kilts JD, Hulette CM, Steffens DC, Blazer DG, Ervin JF, Strauss JL, Allen TB, Massing MW, Payne VM, Youssef NA, Shampine LJ, Marx CE. Naylor JC, et al. Among authors: strauss jl. Biochim Biophys Acta. 2010 Aug;1801(8):951-9. doi: 10.1016/j.bbalip.2010.05.006. Epub 2010 May 19. Biochim Biophys Acta. 2010. PMID: 20488256 Free PMC article.
Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.
Kilts JD, Tupler LA, Keefe FJ, Payne VM, Hamer RM, Naylor JC, Calnaido RP, Morey RA, Strauss JL, Parke G, Massing MW, Youssef NA, Shampine LJ; tVeterans Affairs Mid-Atlantic Mental Illness, Research, Education and Clinical Center Workgroup; Marx CE. Kilts JD, et al. Among authors: strauss jl. Pain Med. 2010 Oct;11(10):1469-76. doi: 10.1111/j.1526-4637.2010.00927.x. Epub 2010 Aug 23. Pain Med. 2010. PMID: 20735755 Free PMC article.
A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.
Naylor JC, Dolber TR, Strauss JL, Kilts JD, Strauman TJ, Bradford DW, Szabo ST, Youssef NA, Connor KM, Davidson JR, Marx CE. Naylor JC, et al. Among authors: strauss jl. Psychiatry Res. 2013 Apr 30;206(2-3):318-20. doi: 10.1016/j.psychres.2012.11.008. Epub 2012 Dec 29. Psychiatry Res. 2013. PMID: 23276723 Free PMC article. Clinical Trial.
A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment.
Naylor JC, Kilts JD, Bradford DW, Strauss JL, Capehart BP, Szabo ST, Smith KD, Dunn CE, Conner KM, Davidson JR, Wagner HR, Hamer RM, Marx CE. Naylor JC, et al. Among authors: strauss jl. Int Clin Psychopharmacol. 2015 May;30(3):167-74. doi: 10.1097/YIC.0000000000000061. Int Clin Psychopharmacol. 2015. PMID: 25647451 Clinical Trial.
Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.
Naylor JC, Hulette CM, Steffens DC, Shampine LJ, Ervin JF, Payne VM, Massing MW, Kilts JD, Strauss JL, Calhoun PS, Calnaido RP, Blazer DG, Lieberman JA, Madison RD, Marx CE. Naylor JC, et al. Among authors: strauss jl. J Clin Endocrinol Metab. 2008 Aug;93(8):3173-8. doi: 10.1210/jc.2007-1229. Epub 2008 May 13. J Clin Endocrinol Metab. 2008. PMID: 18477662 Free PMC article.
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