Thasler WE - Search Results

1

Inferring statin-induced gene regulatory relationships in primary human hepatocytes.

Schröder A, Wollnik J, Wrzodek C, Dräger A, Bonin M, Burk O, Thomas M, Thasler WE, Zanger UM, Zell A. Schröder A, et al. Among authors: thasler we. Bioinformatics. 2011 Sep 15;27(18):2473-7. doi: 10.1093/bioinformatics/btr416. Epub 2011 Jul 14. Bioinformatics. 2011. PMID: 21757465

2

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes.

Feidt DM, Klein K, Hofmann U, Riedmaier S, Knobeloch D, Thasler WE, Weiss TS, Schwab M, Zanger UM. Feidt DM, et al. Among authors: thasler we. Drug Metab Dispos. 2010 Sep;38(9):1589-97. doi: 10.1124/dmd.110.033886. Epub 2010 Jun 15. Drug Metab Dispos. 2010. PMID: 20551241

3

A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes.

Bucher J, Riedmaier S, Schnabel A, Marcus K, Vacun G, Weiss TS, Thasler WE, Nüssler AK, Zanger UM, Reuss M. Bucher J, et al. Among authors: thasler we. BMC Syst Biol. 2011 May 6;5:66. doi: 10.1186/1752-0509-5-66. BMC Syst Biol. 2011. PMID: 21548957 Free PMC article.

4

Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.

Hoffart E, Ghebreghiorghis L, Nussler AK, Thasler WE, Weiss TS, Schwab M, Burk O. Hoffart E, et al. Among authors: thasler we. Br J Pharmacol. 2012 Mar;165(5):1595-608. doi: 10.1111/j.1476-5381.2011.01665.x. Br J Pharmacol. 2012. PMID: 21913896 Free PMC article.

5

No activation of human pregnane X receptor by hyperforin-related phloroglucinols.

Kandel BA, Ekins S, Leuner K, Thasler WE, Harteneck C, Zanger UM. Kandel BA, et al. Among authors: thasler we. J Pharmacol Exp Ther. 2014 Mar;348(3):393-400. doi: 10.1124/jpet.113.209916. Epub 2013 Nov 20. J Pharmacol Exp Ther. 2014. PMID: 24259679

6

Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

Bitter A, Nüssler AK, Thasler WE, Klein K, Zanger UM, Schwab M, Burk O. Bitter A, et al. Among authors: thasler we. Cell Physiol Biochem. 2015;35(2):803-15. doi: 10.1159/000369739. Epub 2015 Jan 30. Cell Physiol Biochem. 2015. PMID: 25634759 Free article.

7

Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling.

Keller R, Klein M, Thomas M, Dräger A, Metzger U, Templin MF, Joos TO, Thasler WE, Zell A, Zanger UM. Keller R, et al. Among authors: thasler we. PLoS Comput Biol. 2016 Jan 4;12(1):e1004431. doi: 10.1371/journal.pcbi.1004431. eCollection 2016 Jan. PLoS Comput Biol. 2016. PMID: 26727233 Free PMC article.

8

Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O. Jeske J, et al. Among authors: thasler we. Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3. Epub 2017 Mar 13. Arch Toxicol. 2017. PMID: 28289823

9

Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O. Jeske J, et al. Among authors: thasler we. Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13. Biochem Pharmacol. 2017. PMID: 28414139

10

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B. Burk O, et al. Among authors: thasler we. Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22. Arch Toxicol. 2018. PMID: 29356861

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