Brahimi F - Search Results

1

A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR-DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity.

Golabi N, Brahimi F, Huang Y, Rachid Z, Qiu Q, Larroque-Lombard AL, Jean-Claude BJ. Golabi N, et al. Among authors: brahimi f. J Pharm Biomed Anal. 2011 Nov 1;56(3):592-9. doi: 10.1016/j.jpba.2011.06.013. Epub 2011 Jun 24. J Pharm Biomed Anal. 2011. PMID: 21764236

2

The combi-targeting concept: a novel 3,3-disubstituted nitrosourea with EGFR tyrosine kinase inhibitory properties.

Qiu Q, Dudouit F, Matheson SL, Brahimi F, Banerjee R, McNamee JP, Jean-Claude BJ. Qiu Q, et al. Among authors: brahimi f. Cancer Chemother Pharmacol. 2003 Jan;51(1):1-10. doi: 10.1007/s00280-002-0524-5. Epub 2002 Nov 1. Cancer Chemother Pharmacol. 2003. PMID: 12497200

3

The combi-targeting concept: chemical dissection of the dual targeting properties of a series of "combi-triazenes".

Rachid Z, Brahimi F, Katsoulas A, Teoh N, Jean-Claude BJ. Rachid Z, et al. Among authors: brahimi f. J Med Chem. 2003 Sep 25;46(20):4313-21. doi: 10.1021/jm030142e. J Med Chem. 2003. PMID: 13678409

4

Multiple mechanisms of action of ZR2002 in human breast cancer cells: a novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA.

Brahimi F, Rachid Z, Qiu Q, McNamee JP, Li YJ, Tari AM, Jean-Claude BJ. Brahimi F, et al. Int J Cancer. 2004 Nov 10;112(3):484-91. doi: 10.1002/ijc.20383. Int J Cancer. 2004. PMID: 15382076

5

[Combi-molecules: a global approach towards better chemoselectivity and chemosensitivity].

Matheson S, Qiu Q, Brahimi F, Dudouit F, Banerjee R, Rachid Z, Jean-Claude BJ. Matheson S, et al. Among authors: brahimi f. Bull Cancer. 2004 Dec;91(12):911-5. Bull Cancer. 2004. PMID: 15634632 Free article. French.

6

Synthesis of half-mustard combi-molecules with fluorescence properties: correlation with EGFR status.

Rachid Z, Brahimi F, Domarkas J, Jean-Claude BJ. Rachid Z, et al. Among authors: brahimi f. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1135-8. doi: 10.1016/j.bmcl.2004.12.015. Bioorg Med Chem Lett. 2005. PMID: 15686928

7

Mechanism of action of a novel "combi-triazene" engineered to possess a polar functional group on the alkylating moiety: evidence for enhancement of potency.

Brahimi F, Rachid Z, McNamee JP, Alaoui-Jamali MA, Tari AM, Jean-Claude BJ. Brahimi F, et al. Biochem Pharmacol. 2005 Aug 15;70(4):511-9. doi: 10.1016/j.bcp.2005.04.037. Biochem Pharmacol. 2005. PMID: 15982640

8

The combi-targeting concept: evidence for the formation of a novel inhibitor in vivo.

Merayo N, Rachid Z, Qiu Q, Brahimi F, Jean-Claude BJ. Merayo N, et al. Among authors: brahimi f. Anticancer Drugs. 2006 Feb;17(2):165-71. doi: 10.1097/00001813-200602000-00007. Anticancer Drugs. 2006. PMID: 16428934

9

The combi-targeting concept: in vitro and in vivo fragmentation of a stable combi-nitrosourea engineered to interact with the epidermal growth factor receptor while remaining DNA reactive.

Qiu Q, Domarkas J, Banerjee R, Merayo N, Brahimi F, McNamee JP, Gibbs BF, Jean-Claude BJ. Qiu Q, et al. Among authors: brahimi f. Clin Cancer Res. 2007 Jan 1;13(1):331-40. doi: 10.1158/1078-0432.CCR-06-0812. Clin Cancer Res. 2007. PMID: 17200372

10

Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: discovery of an unusual structure-activity relationship.

Rachid Z, Brahimi F, Qiu Q, Williams C, Hartley JM, Hartley JA, Jean-Claude BJ. Rachid Z, et al. Among authors: brahimi f. J Med Chem. 2007 May 31;50(11):2605-8. doi: 10.1021/jm070144p. Epub 2007 May 2. J Med Chem. 2007. PMID: 17472358

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