Houslay MD - Search Results

1

The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrations.

Houslay MD. Houslay MD. Cell Signal. 1990;2(1):85-98. doi: 10.1016/0898-6568(90)90036-a. Cell Signal. 1990. PMID: 2176803

2

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.

Michie AM, Lobban M, Müller T, Harnett MM, Houslay MD. Michie AM, et al. Among authors: houslay md. Cell Signal. 1996 Feb;8(2):97-110. doi: 10.1016/0898-6568(95)02032-2. Cell Signal. 1996. PMID: 8730511

3

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.

McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: houslay md. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070

4

Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.

Houslay MD, Gawler DJ, Milligan G, Wilson A. Houslay MD, et al. Cell Signal. 1989;1(1):9-22. doi: 10.1016/0898-6568(89)90016-8. Cell Signal. 1989. PMID: 2561940

5

Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.

Palmer TM, Taberner PV, Houslay MD. Palmer TM, et al. Among authors: houslay md. Cell Signal. 1992 Jul;4(4):365-77. doi: 10.1016/0898-6568(92)90031-3. Cell Signal. 1992. PMID: 1419480

6

Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.

Murphy GJ, Houslay MD. Murphy GJ, et al. Among authors: houslay md. Biochem J. 1988 Jan 15;249(2):543-7. doi: 10.1042/bj2490543. Biochem J. 1988. PMID: 2449179 Free PMC article.

7

An insulin mediator preparation serves to stimulate the cyclic GMP activated cyclic AMP phosphodiesterase rather than other purified insulin-activated cyclic AMP phosphodiesterases.

Pyne NJ, Houslay MD. Pyne NJ, et al. Among authors: houslay md. Biochem Biophys Res Commun. 1988 Oct 14;156(1):290-6. doi: 10.1016/s0006-291x(88)80838-6. Biochem Biophys Res Commun. 1988. PMID: 2845976

8

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

McCahill A, Campbell L, McSorley T, Sood A, Lynch MJ, Li X, Yan C, Baillie GS, Houslay MD. McCahill A, et al. Among authors: houslay md. Cell Signal. 2008 Nov;20(11):2071-83. doi: 10.1016/j.cellsig.2008.07.017. Epub 2008 Aug 5. Cell Signal. 2008. PMID: 18721873

9

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.

Sheppard CL, Lee LC, Hill EV, Henderson DJ, Anthony DF, Houslay DM, Yalla KC, Cairns LS, Dunlop AJ, Baillie GS, Huston E, Houslay MD. Sheppard CL, et al. Among authors: houslay dm, houslay md. Cell Signal. 2014 Sep;26(9):1958-74. doi: 10.1016/j.cellsig.2014.04.023. Epub 2014 May 9. Cell Signal. 2014. PMID: 24815749

10

Activation and phosphorylation of the 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase.

Kilgour E, Anderson NG, Houslay MD. Kilgour E, et al. Among authors: houslay md. Biochem J. 1989 May 15;260(1):27-36. doi: 10.1042/bj2600027. Biochem J. 1989. PMID: 2549954 Free PMC article.

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