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Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interaction.
Yan M, Zhang X, Chen A, Gu W, Liu J, Ren X, Zhang J, Wu X, Place AT, Minshall RD, Liu G. Yan M, et al. Among authors: liu j, liu g. FASEB J. 2017 Nov;31(11):4759-4769. doi: 10.1096/fj.201700280R. Epub 2017 Jul 12. FASEB J. 2017. PMID: 28701303 Free PMC article.
These results suggest that SHP-2-via association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching association with ICAM-1 or actin, thereby negatively regulating neutrophil adhesion to endothelial cells and enhancing their TEM.-Yan, M., Zhang …
These results suggest that SHP-2-via association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching asso …
G protein-dependent basal and evoked endothelial cell vWF secretion.
Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD. Rusu L, et al. Among authors: liu g. Blood. 2014 Jan 16;123(3):442-50. doi: 10.1182/blood-2013-03-489351. Epub 2013 Sep 30. Blood. 2014. PMID: 24081657 Free PMC article.
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