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Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
Miller M, Shi J, Zhu Y, Kustov M, Tian JB, Stevens A, Wu M, Xu J, Long S, Yang P, Zholos AV, Salovich JM, Weaver CD, Hopkins CR, Lindsley CW, McManus O, Li M, Zhu MX. Miller M, et al. Among authors: lindsley cw. J Biol Chem. 2011 Sep 23;286(38):33436-46. doi: 10.1074/jbc.M111.274167. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795696 Free PMC article.
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
Bridges TM, Marlo JE, Niswender CM, Jones CK, Jadhav SB, Gentry PR, Plumley HC, Weaver CD, Conn PJ, Lindsley CW. Bridges TM, et al. Among authors: lindsley cw. J Med Chem. 2009 Jun 11;52(11):3445-8. doi: 10.1021/jm900286j. J Med Chem. 2009. PMID: 19438238 Free PMC article.
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe.
Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW. Weaver CD, et al. Among authors: lindsley cw. Curr Top Med Chem. 2009;9(13):1217-26. doi: 10.2174/156802609789753635. Curr Top Med Chem. 2009. PMID: 19807667 Free PMC article. Review.
761 results