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The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
Crouch PJ, Savva MS, Hung LW, Donnelly PS, Mot AI, Parker SJ, Greenough MA, Volitakis I, Adlard PA, Cherny RA, Masters CL, Bush AI, Barnham KJ, White AR. Crouch PJ, et al. Among authors: masters cl. J Neurochem. 2011 Oct;119(1):220-30. doi: 10.1111/j.1471-4159.2011.07402.x. Epub 2011 Aug 25. J Neurochem. 2011. PMID: 21797865 Free article.
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Opazo C, et al. Among authors: masters cl. J Biol Chem. 2002 Oct 25;277(43):40302-8. doi: 10.1074/jbc.M206428200. Epub 2002 Aug 20. J Biol Chem. 2002. PMID: 12192006 Free article.
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R. Barnham KJ, et al. Among authors: masters cl. J Biol Chem. 2003 May 9;278(19):17401-7. doi: 10.1074/jbc.M300629200. Epub 2003 Feb 28. J Biol Chem. 2003. PMID: 12611883 Free article.
Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.
White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R. White AR, et al. Among authors: masters cl. Brain Res. 2003 Mar 21;966(2):231-44. doi: 10.1016/s0006-8993(02)04173-2. Brain Res. 2003. PMID: 12618346
1,020 results