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Page 1
Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors.
Abraham S, Hadd MJ, Tran L, Vickers T, Sindac J, Milanov ZV, Holladay MW, Bhagwat SS, Hua H, Ford Pulido JM, Cramer MD, Gitnick D, James J, Dao A, Belli B, Armstrong RC, Treiber DK, Liu G. Abraham S, et al. Among authors: tran l. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5296-300. doi: 10.1016/j.bmcl.2011.07.027. Epub 2011 Jul 14. Bioorg Med Chem Lett. 2011. PMID: 21802948
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Holladay MW, Campbell BT, Rowbottom MW, Chao Q, Sprankle KG, Lai AG, Abraham S, Setti E, Faraoni R, Tran L, Armstrong RC, Gunawardane RN, Gardner MF, Cramer MD, Gitnick D, Ator MA, Dorsey BD, Ruggeri BR, Williams M, Bhagwat SS, James J. Holladay MW, et al. Among authors: tran l. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5342-6. doi: 10.1016/j.bmcl.2011.07.019. Epub 2011 Jul 14. Bioorg Med Chem Lett. 2011. PMID: 21807507
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
Rowbottom MW, Faraoni R, Chao Q, Campbell BT, Lai AG, Setti E, Ezawa M, Sprankle KG, Abraham S, Tran L, Struss B, Gibney M, Armstrong RC, Gunawardane RN, Nepomuceno RR, Valenta I, Hua H, Gardner MF, Cramer MD, Gitnick D, Insko DE, Apuy JL, Jones-Bolin S, Ghose AK, Herbertz T, Ator MA, Dorsey BD, Ruggeri B, Williams M, Bhagwat S, James J, Holladay MW. Rowbottom MW, et al. Among authors: tran l. J Med Chem. 2012 Feb 9;55(3):1082-105. doi: 10.1021/jm2009925. Epub 2012 Jan 23. J Med Chem. 2012. PMID: 22168626
Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index.
Liu G, Abraham S, Tran L, Vickers TD, Xu S, Hadd MJ, Quiambao S, Holladay MW, Hua H, Ford Pulido JM, Gunawardane RN, Davis MI, Eichelberger SR, Apuy JL, Gitnick D, Gardner MF, James J, Breider MA, Belli B, Armstrong RC, Treiber DK. Liu G, et al. Among authors: tran l. J Med Chem. 2012 Apr 12;55(7):3250-60. doi: 10.1021/jm201702g. Epub 2012 Mar 14. J Med Chem. 2012. PMID: 22380736
Synthesis and antitumor activity of ester-modified analogues of bengamide B.
Kinder FR Jr, Versace RW, Bair KW, Bontempo JM, Cesarz D, Chen S, Crews P, Czuchta AM, Jagoe CT, Mou Y, Nemzek R, Phillips PE, Tran LD, Wang RM, Weltchek S, Zabludoff S. Kinder FR Jr, et al. Among authors: tran ld. J Med Chem. 2001 Oct 25;44(22):3692-9. doi: 10.1021/jm010188c. J Med Chem. 2001. PMID: 11606134
Total syntheses of bengamides B and E.
Kinder FR Jr, Wattanasin S, Versace RW, Bair KW, Bontempo J, Green MA, Lu YJ, Marepalli HR, Phillips PE, Roche D, Tran LD, Wang R, Waykole L, Xu DD, Zabludoff S. Kinder FR Jr, et al. Among authors: tran ld. J Org Chem. 2001 Mar 23;66(6):2118-22. doi: 10.1021/jo0017133. J Org Chem. 2001. PMID: 11300909
Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures.
Kabiljo J, Theophil A, Homola J, Renner AF, Stürzenbecher N, Ammon D, Zirnbauer R, Stang S, Tran L, Laengle J, Kulu A, Chen A, Fabits M, Atanasova VS, Pusch O, Weninger W, Walczak H, Herndler Brandstetter D, Egger G, Dolznig H, Kusienicka A, Farlik M, Bergmann M. Kabiljo J, et al. Among authors: tran l. J Immunother Cancer. 2024 Nov 4;12(11):e009494. doi: 10.1136/jitc-2024-009494. J Immunother Cancer. 2024. PMID: 39500527 Free PMC article.
The Lancet Public Health Commission on gambling.
Wardle H, Degenhardt L, Marionneau V, Reith G, Livingstone C, Sparrow M, Tran LT, Biggar B, Bunn C, Farrell M, Kesaite V, Poznyak V, Quan J, Rehm J, Rintoul A, Sharma M, Shiffman J, Siste K, Ukhova D, Volberg R, Salifu Yendork J, Saxena S. Wardle H, et al. Among authors: tran lt. Lancet Public Health. 2024 Oct 16:S2468-2667(24)00167-1. doi: 10.1016/S2468-2667(24)00167-1. Online ahead of print. Lancet Public Health. 2024. PMID: 39491880 Free article. Review. No abstract available.
Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote Ovarian Cancer Malignancy.
Horst EN, Cotter LR, Bonini M, Novak CM, Treacher NM, Zhang Y, Jackson ZF, Narayanan IV, Fischer ZS, Sunshine AR, Lin Z, Tran LA, Ljungman M, Maturen KE, DiFeo A, Nordsletten DA, Mehta G. Horst EN, et al. Among authors: tran la. Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-5160301. doi: 10.21203/rs.3.rs-5160301/v1. Res Sq. 2024. PMID: 39483899 Free PMC article. Preprint.
2,022 results