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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
Kim RH, Smith PD, Aleyasin H, Hayley S, Mount MP, Pownall S, Wakeham A, You-Ten AJ, Kalia SK, Horne P, Westaway D, Lozano AM, Anisman H, Park DS, Mak TW. Kim RH, et al. Among authors: mak tw. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5215-20. doi: 10.1073/pnas.0501282102. Epub 2005 Mar 22. Proc Natl Acad Sci U S A. 2005. PMID: 15784737 Free PMC article.
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.
Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW. Sasaki M, et al. Among authors: mak tw. Nature. 2012 Aug 30;488(7413):656-9. doi: 10.1038/nature11323. Nature. 2012. PMID: 22763442 Free PMC article.
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. Sasaki M, et al. Among authors: mak tw. Genes Dev. 2012 Sep 15;26(18):2038-49. doi: 10.1101/gad.198200.112. Epub 2012 Aug 27. Genes Dev. 2012. PMID: 22925884 Free PMC article.
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
Brüstle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, Reardon C, Lacher SM, Ruland J, Ohashi PS, Mak TW. Brüstle A, et al. Among authors: mak tw. J Clin Invest. 2012 Dec;122(12):4698-709. doi: 10.1172/JCI63528. Epub 2012 Nov 1. J Clin Invest. 2012. PMID: 23114599 Free PMC article.
Regulation of the VHL/HIF-1 pathway by DJ-1.
Parsanejad M, Zhang Y, Qu D, Irrcher I, Rousseaux MW, Aleyasin H, Kamkar F, Callaghan S, Slack RS, Mak TW, Lee S, Figeys D, Park DS. Parsanejad M, et al. Among authors: mak tw. J Neurosci. 2014 Jun 4;34(23):8043-50. doi: 10.1523/JNEUROSCI.1244-13.2014. J Neurosci. 2014. PMID: 24899725 Free PMC article.
DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.
Parsanejad M, Bourquard N, Qu D, Zhang Y, Huang E, Rousseaux MW, Aleyasin H, Irrcher I, Callaghan S, Vaillant DC, Kim RH, Slack RS, Mak TW, Reddy ST, Figeys D, Park DS. Parsanejad M, et al. Among authors: mak tw. PLoS One. 2014 Sep 11;9(9):e106601. doi: 10.1371/journal.pone.0106601. eCollection 2014. PLoS One. 2014. PMID: 25210784 Free PMC article.
1,086 results