Fairlamb AH - Search Results

1

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

Smith VC, Cleghorn LA, Woodland A, Spinks D, Hallyburton I, Collie IT, Mok NY, Norval S, Brenk R, Fairlamb AH, Frearson JA, Read KD, Gilbert IH, Wyatt PG. Smith VC, et al. Among authors: fairlamb ah. ChemMedChem. 2011 Oct 4;6(10):1832-40. doi: 10.1002/cmdc.201100278. Epub 2011 Aug 10. ChemMedChem. 2011. PMID: 21834094 Free PMC article.

2

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

Tye CK, Kasinathan G, Barrett MP, Brun R, Doyle VE, Fairlamb AH, Weaver R, Gilbert IH. Tye CK, et al. Among authors: fairlamb ah. Bioorg Med Chem Lett. 1998 Apr 7;8(7):811-6. doi: 10.1016/s0960-894x(98)00095-x. Bioorg Med Chem Lett. 1998. PMID: 9871546

3

Target assessment for antiparasitic drug discovery.

Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Frearson JA, et al. Among authors: fairlamb ah. Trends Parasitol. 2007 Dec;23(12):589-95. doi: 10.1016/j.pt.2007.08.019. Epub 2007 Oct 24. Trends Parasitol. 2007. PMID: 17962072 Free PMC article. Review.

4

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. Mpamhanga CP, et al. Among authors: fairlamb ah. J Med Chem. 2009 Jul 23;52(14):4454-65. doi: 10.1021/jm900414x. J Med Chem. 2009. PMID: 19527033 Free PMC article.

5

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

Richardson JL, Nett IR, Jones DC, Abdille MH, Gilbert IH, Fairlamb AH. Richardson JL, et al. Among authors: fairlamb ah. ChemMedChem. 2009 Aug;4(8):1333-40. doi: 10.1002/cmdc.200900097. ChemMedChem. 2009. PMID: 19557801 Free PMC article.

6

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

Patterson S, Jones DC, Shanks EJ, Frearson JA, Gilbert IH, Wyatt PG, Fairlamb AH. Patterson S, et al. Among authors: fairlamb ah. ChemMedChem. 2009 Aug;4(8):1341-53. doi: 10.1002/cmdc.200900098. ChemMedChem. 2009. PMID: 19557802 Free PMC article.

7

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.

Wyllie S, Oza SL, Patterson S, Spinks D, Thompson S, Fairlamb AH. Wyllie S, et al. Among authors: fairlamb ah. Mol Microbiol. 2009 Nov;74(3):529-40. doi: 10.1111/j.1365-2958.2009.06761.x. Epub 2009 Jun 24. Mol Microbiol. 2009. PMID: 19558432 Free PMC article.

8

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi.

Jones DC, Ariza A, Chow WH, Oza SL, Fairlamb AH. Jones DC, et al. Among authors: fairlamb ah. Mol Biochem Parasitol. 2010 Jan;169(1):12-9. doi: 10.1016/j.molbiopara.2009.09.002. Epub 2009 Sep 10. Mol Biochem Parasitol. 2010. PMID: 19747949 Free PMC article.

9

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase.

Shanks EJ, Ong HB, Robinson DA, Thompson S, Sienkiewicz N, Fairlamb AH, Frearson JA. Shanks EJ, et al. Among authors: fairlamb ah. Anal Biochem. 2010 Jan 15;396(2):194-203. doi: 10.1016/j.ab.2009.09.003. Epub 2009 Sep 11. Anal Biochem. 2010. PMID: 19748480 Free PMC article.

10

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

Torrie LS, Wyllie S, Spinks D, Oza SL, Thompson S, Harrison JR, Gilbert IH, Wyatt PG, Fairlamb AH, Frearson JA. Torrie LS, et al. Among authors: fairlamb ah. J Biol Chem. 2009 Dec 25;284(52):36137-36145. doi: 10.1074/jbc.M109.045336. Epub 2009 Oct 14. J Biol Chem. 2009. PMID: 19828449 Free PMC article.

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