Enhanced sampling and overfitting analyses in structural refinement of nucleic acids into electron microscopy maps.
Vashisth H, Skiniotis G, Brooks CL 3rd.
Vashisth H, et al.
J Phys Chem B. 2013 Apr 11;117(14):3738-46. doi: 10.1021/jp3126297. Epub 2013 Apr 1.
J Phys Chem B. 2013.
PMID: 23506287
Free PMC article.
We have previously shown that MDFF simulations of globular proteins are sensitive to the resolution of the target EM map and the strength of restraints used to preserve the secondary structure elements during fitting (Vashisth, H.; et al. Structure 2012, 20, 1453-14 …
We have previously shown that MDFF simulations of globular proteins are sensitive to the resolution of the target EM map and the strength of …