Gottlieb E - Search Results

1

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E. Frezza C, et al. Among authors: gottlieb e. Nature. 2011 Aug 17;477(7363):225-8. doi: 10.1038/nature10363. Nature. 2011. PMID: 21849978

2

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.

Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E. Selak MA, et al. Among authors: gottlieb e. Cancer Cell. 2005 Jan;7(1):77-85. doi: 10.1016/j.ccr.2004.11.022. Cancer Cell. 2005. PMID: 15652751 Free article.

3

Mitochondrial tumour suppressors: a genetic and biochemical update.

Gottlieb E, Tomlinson IP. Gottlieb E, et al. Nat Rev Cancer. 2005 Nov;5(11):857-66. doi: 10.1038/nrc1737. Nat Rev Cancer. 2005. PMID: 16327764 Review.

4

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

King A, Selak MA, Gottlieb E. King A, et al. Among authors: gottlieb e. Oncogene. 2006 Aug 7;25(34):4675-82. doi: 10.1038/sj.onc.1209594. Oncogene. 2006. PMID: 16892081 Review.

5

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells.

MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E. MacKenzie ED, et al. Among authors: gottlieb e. Mol Cell Biol. 2007 May;27(9):3282-9. doi: 10.1128/MCB.01927-06. Epub 2007 Feb 26. Mol Cell Biol. 2007. PMID: 17325041 Free PMC article.

6

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria.

Gonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJ, Petit PX, Vaz FM, Gottlieb E. Gonzalvez F, et al. Among authors: gottlieb e. J Cell Biol. 2008 Nov 17;183(4):681-96. doi: 10.1083/jcb.200803129. Epub 2008 Nov 10. J Cell Biol. 2008. PMID: 19001123 Free PMC article.

7

Mitochondria in cancer: not just innocent bystanders.

Frezza C, Gottlieb E. Frezza C, et al. Among authors: gottlieb e. Semin Cancer Biol. 2009 Feb;19(1):4-11. doi: 10.1016/j.semcancer.2008.11.008. Epub 2008 Dec 3. Semin Cancer Biol. 2009. PMID: 19101633 Review.

8

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

Tennant DA, Frezza C, MacKenzie ED, Nguyen QD, Zheng L, Selak MA, Roberts DL, Dive C, Watson DG, Aboagye EO, Gottlieb E. Tennant DA, et al. Among authors: gottlieb e. Oncogene. 2009 Nov 12;28(45):4009-21. doi: 10.1038/onc.2009.250. Epub 2009 Aug 31. Oncogene. 2009. PMID: 19718054

9

IDH1 mutations in gliomas: when an enzyme loses its grip.

Frezza C, Tennant DA, Gottlieb E. Frezza C, et al. Among authors: gottlieb e. Cancer Cell. 2010 Jan 19;17(1):7-9. doi: 10.1016/j.ccr.2009.12.031. Cancer Cell. 2010. PMID: 20129244 Free article.

10

Targeting metabolic transformation for cancer therapy.

Tennant DA, Durán RV, Gottlieb E. Tennant DA, et al. Among authors: gottlieb e. Nat Rev Cancer. 2010 Apr;10(4):267-77. doi: 10.1038/nrc2817. Epub 2010 Mar 19. Nat Rev Cancer. 2010. PMID: 20300106 Review.

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