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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E. Frezza C, et al. Among authors: kalna g. Nature. 2011 Aug 17;477(7363):225-8. doi: 10.1038/nature10363. Nature. 2011. PMID: 21849978
Fumarate induces redox-dependent senescence by modifying glutathione metabolism.
Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JD, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, Gottlieb E. Zheng L, et al. Among authors: kalna g. Nat Commun. 2015 Jan 23;6:6001. doi: 10.1038/ncomms7001. Nat Commun. 2015. PMID: 25613188 Free PMC article.
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Cardaci S, Zheng L, MacKay G, van den Broek NJ, MacKenzie ED, Nixon C, Stevenson D, Tumanov S, Bulusu V, Kamphorst JJ, Vazquez A, Fleming S, Schiavi F, Kalna G, Blyth K, Strathdee D, Gottlieb E. Cardaci S, et al. Among authors: kalna g. Nat Cell Biol. 2015 Oct;17(10):1317-26. doi: 10.1038/ncb3233. Epub 2015 Aug 24. Nat Cell Biol. 2015. PMID: 26302408 Free PMC article.
Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells.
Carruthers RD, Ahmed SU, Ramachandran S, Strathdee K, Kurian KM, Hedley A, Gomez-Roman N, Kalna G, Neilson M, Gilmour L, Stevenson KH, Hammond EM, Chalmers AJ. Carruthers RD, et al. Among authors: kalna g. Cancer Res. 2018 Sep 1;78(17):5060-5071. doi: 10.1158/0008-5472.CAN-18-0569. Epub 2018 Jul 5. Cancer Res. 2018. PMID: 29976574 Free PMC article.
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJ, Schulze A, Gottlieb E. Schug ZT, et al. Among authors: kalna g. Cancer Cell. 2015 Jan 12;27(1):57-71. doi: 10.1016/j.ccell.2014.12.002. Cancer Cell. 2015. PMID: 25584894 Free PMC article.
55 results