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Page 1
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.
Wang L, Desmoulin SK, Cherian C, Polin L, White K, Kushner J, Fulterer A, Chang MH, Mitchell-Ryan S, Stout M, Romero MF, Hou Z, Matherly LH, Gangjee A. Wang L, et al. Among authors: polin l. J Med Chem. 2011 Oct 27;54(20):7150-64. doi: 10.1021/jm200739e. Epub 2011 Sep 22. J Med Chem. 2011. PMID: 21879757 Free PMC article.
Senescence-associated secretory proteins induced in lung adenocarcinoma by extended treatment with dexamethasone enhance migration and activation of lymphocytes.
Parajuli P, Rosati R, Mamdani H, Wright RE 3rd, Hussain Z, Naeem A, Dzinic S, Polin L, Gavande NS, Ratnam M. Parajuli P, et al. Among authors: polin l. Cancer Immunol Immunother. 2023 May;72(5):1273-1284. doi: 10.1007/s00262-022-03332-z. Epub 2022 Nov 25. Cancer Immunol Immunother. 2023. PMID: 36434273 Free PMC article.
ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.
Heyza JR, Ekinci E, Lindquist J, Lei W, Yunker C, Vinothkumar V, Rowbotham R, Polin L, Snider NG, Van Buren E, Watza D, Back JB, Chen W, Mamdani H, Schwartz AG, Turchi JJ, Bepler G, Patrick SM. Heyza JR, et al. Among authors: polin l. NAR Cancer. 2023 Jan 11;5(1):zcac045. doi: 10.1093/narcan/zcac045. eCollection 2023 Mar. NAR Cancer. 2023. PMID: 36644397 Free PMC article.
II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
Hazeldine ST, Polin L, Kushner J, White K, Bouregeois NM, Crantz B, Palomino E, Corbett TH, Horwitz JP. Hazeldine ST, et al. Among authors: polin l. J Med Chem. 2002 Jul 4;45(14):3130-7. doi: 10.1021/jm0200097. J Med Chem. 2002. PMID: 12086498
The synthetic approach to each of the bioisosteres of 1 utilized the methodology developed in previous work (see Hazeldine, S. T.; Polin, L.; Kushner, J.; Paluch, J.; White, K.; Edelstein, M.; Palomino, E.; Corbett, T. ...
The synthetic approach to each of the bioisosteres of 1 utilized the methodology developed in previous work (see Hazeldine, S. T.; Polin …
Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors.
Liang J, Moore RE, Moher ED, Munroe JE, Al-awar RS, Hay DA, Varie DL, Zhang TY, Aikins JA, Martinelli MJ, Shih C, Ray JE, Gibson LL, Vasudevan V, Polin L, White K, Kushner J, Simpson C, Pugh S, Corbett TH. Liang J, et al. Among authors: polin l. Invest New Drugs. 2005 Jun;23(3):213-24. doi: 10.1007/s10637-005-6729-9. Invest New Drugs. 2005. PMID: 15868377
117 results