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Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR. Choi JH, et al. Among authors: kumar n. Nature. 2011 Sep 4;477(7365):477-81. doi: 10.1038/nature10383. Nature. 2011. PMID: 21892191 Free PMC article.
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, Istrate MA, Kamenecka TM, Roush WR, Vidović D, Schürer SC, Xu J, Wagoner G, Drew PD, Griffin PR, Burris TP. Solt LA, et al. Among authors: kumar n. Nature. 2011 Apr 28;472(7344):491-4. doi: 10.1038/nature10075. Epub 2011 Apr 17. Nature. 2011. PMID: 21499262 Free PMC article.
Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists.
Asteian A, Blayo AL, He Y, Koenig M, Shin Y, Kuruvilla DS, Corzo CA, Cameron MD, Lin L, Ruiz C, Khan S, Kumar N, Busby S, Marciano DP, Garcia-Ordonez RD, Griffin PR, Kamenecka TM. Asteian A, et al. Among authors: kumar n. ACS Med Chem Lett. 2015 Aug 4;6(9):998-1003. doi: 10.1021/acsmedchemlett.5b00218. eCollection 2015 Sep 10. ACS Med Chem Lett. 2015. PMID: 26396687 Free PMC article.
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.
Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Kumar N, et al. Among authors: kumar kg. ACS Chem Biol. 2011 Mar 18;6(3):218-22. doi: 10.1021/cb1002762. Epub 2010 Dec 6. ACS Chem Biol. 2011. PMID: 21090593 Free PMC article.
Small molecule amides as potent ROR-γ selective modulators.
Khan PM, El-Gendy Bel-D, Kumar N, Garcia-Ordonez R, Lin L, Ruiz CH, Cameron MD, Griffin PR, Kamenecka TM. Khan PM, et al. Among authors: kumar n. Bioorg Med Chem Lett. 2013 Jan 15;23(2):532-6. doi: 10.1016/j.bmcl.2012.11.025. Epub 2012 Nov 22. Bioorg Med Chem Lett. 2013. PMID: 23232056 Free PMC article.
The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.
Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR. Kumar N, et al. Mol Pharmacol. 2010 Feb;77(2):228-36. doi: 10.1124/mol.109.060905. Epub 2009 Nov 3. Mol Pharmacol. 2010. PMID: 19887649 Free PMC article.
Regulation of adipogenesis by natural and synthetic REV-ERB ligands.
Kumar N, Solt LA, Wang Y, Rogers PM, Bhattacharyya G, Kamenecka TM, Stayrook KR, Crumbley C, Floyd ZE, Gimble JM, Griffin PR, Burris TP. Kumar N, et al. Endocrinology. 2010 Jul;151(7):3015-25. doi: 10.1210/en.2009-0800. Epub 2010 Apr 28. Endocrinology. 2010. PMID: 20427485 Free PMC article.
9,273 results