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Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus.
Hartman TL, Yang L, Helfrick AN, Hassink M, Shank NI, George Rosenker K, Scerba MT, Saha M, Hughes E, Wang AQ, Xu X, Gupta P, Buckheit RW Jr, Appella DH. Hartman TL, et al. Among authors: yang l. Antiviral Res. 2016 Oct;134:216-225. doi: 10.1016/j.antiviral.2016.08.022. Epub 2016 Aug 26. Antiviral Res. 2016. PMID: 27568924 Free PMC article.
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Wang D, Iera J, Baker H, Hogan P, Ptak R, Yang L, Hartman T, Buckheit RW Jr, Desjardins A, Yang A, Legault P, Yedavalli V, Jeang KT, Appella DH. Wang D, et al. Among authors: yang a, yang l. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6893-7. doi: 10.1016/j.bmcl.2009.10.078. Epub 2009 Oct 23. Bioorg Med Chem Lett. 2009. PMID: 19896372 Free PMC article.
In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122.
Ottosen S, Parsley TB, Yang L, Zeh K, van Doorn LJ, van der Veer E, Raney AK, Hodges MR, Patick AK. Ottosen S, et al. Among authors: yang l. Antimicrob Agents Chemother. 2015 Jan;59(1):599-608. doi: 10.1128/AAC.04220-14. Epub 2014 Nov 10. Antimicrob Agents Chemother. 2015. PMID: 25385103 Free PMC article. Clinical Trial.
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