Hirai K - Search Results

1

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists.

Fujimoto T, Kunitomo J, Tomata Y, Nishiyama K, Nakashima M, Hirozane M, Yoshikubo S, Hirai K, Marui S. Fujimoto T, et al. Among authors: hirai k. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6414-6. doi: 10.1016/j.bmcl.2011.08.093. Epub 2011 Aug 30. Bioorg Med Chem Lett. 2011. PMID: 21917455

2

Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.

Koike T, Takai T, Hoashi Y, Nakayama M, Kosugi Y, Nakashima M, Yoshikubo S, Hirai K, Uchikawa O. Koike T, et al. Among authors: hirai k. J Med Chem. 2011 Jun 23;54(12):4207-18. doi: 10.1021/jm200385u. Epub 2011 May 24. J Med Chem. 2011. PMID: 21568291

3

Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.

Hoashi Y, Takai T, Kosugi Y, Nakashima M, Nakayama M, Hirai K, Uchikawa O, Koike T. Hoashi Y, et al. Among authors: hirai k. J Med Chem. 2021 Mar 25;64(6):3059-3074. doi: 10.1021/acs.jmedchem.0c01836. Epub 2021 Mar 7. J Med Chem. 2021. PMID: 33682410

4

The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.

Nishiyama K, Hirai K. Nishiyama K, et al. Among authors: hirai k. PLoS One. 2014 Jul 11;9(7):e102073. doi: 10.1371/journal.pone.0102073. eCollection 2014. PLoS One. 2014. PMID: 25013953 Free PMC article.

5

In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor: possible link between duration of action and dissociation rate from receptor.

Nishiyama K, Hirai K. Nishiyama K, et al. Among authors: hirai k. Eur J Pharmacol. 2015 Jun 15;757:42-52. doi: 10.1016/j.ejphar.2015.03.009. Epub 2015 Mar 20. Eur J Pharmacol. 2015. PMID: 25797281

6

Molecular cloning and pharmacological characterization of monkey MT1 and MT2 melatonin receptors showing high affinity for the agonist ramelteon.

Nishiyama K, Shintani Y, Hirai K, Yoshikubo S. Nishiyama K, et al. Among authors: hirai k. J Pharmacol Exp Ther. 2009 Sep;330(3):855-63. doi: 10.1124/jpet.109.155283. Epub 2009 Jun 25. J Pharmacol Exp Ther. 2009. PMID: 19556449

7

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

Nishizawa R, Nishiyama T, Hisaichi K, Hirai K, Habashita H, Takaoka Y, Tada H, Sagawa K, Shibayama S, Maeda K, Mitsuya H, Nakai H, Fukushima D, Toda M. Nishizawa R, et al. Among authors: hirai k. Bioorg Med Chem. 2010 Jul 15;18(14):5208-23. doi: 10.1016/j.bmc.2010.05.057. Epub 2010 May 25. Bioorg Med Chem. 2010. PMID: 20542438 Free PMC article.

8

Pharmacological characterization of M-II, the major human metabolite of ramelteon.

Nishiyama K, Nishikawa H, Kato K, Miyamoto M, Tsukamoto T, Hirai K. Nishiyama K, et al. Among authors: hirai k. Pharmacology. 2014;93(3-4):197-201. doi: 10.1159/000362459. Epub 2014 Jun 6. Pharmacology. 2014. PMID: 24923230

9

Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist.

Kato K, Hirai K, Nishiyama K, Uchikawa O, Fukatsu K, Ohkawa S, Kawamata Y, Hinuma S, Miyamoto M. Kato K, et al. Among authors: hirai k. Neuropharmacology. 2005 Feb;48(2):301-10. doi: 10.1016/j.neuropharm.2004.09.007. Neuropharmacology. 2005. PMID: 15695169

10

[Preclinical pharmacological profiles and clinical outcome of the novel melatonin-receptor agonist ramelteon (Rozerem 8 mg).].

Hirai K, Kato K, Nishikawa H, Yukuhiro N, Nishiyama K, Miyamoto M. Hirai K, et al. Nihon Yakurigaku Zasshi. 2010 Jul;136(1):51-60. doi: 10.1254/fpj.136.51. Nihon Yakurigaku Zasshi. 2010. PMID: 20628215 Review. Japanese. No abstract available.

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