Prakash TP - Search Results

1

Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.

Egli M, Pallan PS, Allerson CR, Prakash TP, Berdeja A, Yu J, Lee S, Watt A, Gaus H, Bhat B, Swayze EE, Seth PP. Egli M, et al. Among authors: prakash tp. J Am Chem Soc. 2011 Oct 19;133(41):16642-9. doi: 10.1021/ja207086x. Epub 2011 Sep 22. J Am Chem Soc. 2011. PMID: 21919455 Free PMC article.

2

Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.

Pattanayek R, Sethaphong L, Pan C, Prhavc M, Prakash TP, Manoharan M, Egli M. Pattanayek R, et al. Among authors: prakash tp. J Am Chem Soc. 2004 Nov 24;126(46):15006-7. doi: 10.1021/ja044637k. J Am Chem Soc. 2004. PMID: 15547979

3

A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.

Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M. Pallan PS, et al. Among authors: prakash tp. Chem Commun (Camb). 2009 Apr 21;(15):2017-9. doi: 10.1039/b822781k. Epub 2009 Feb 26. Chem Commun (Camb). 2009. PMID: 19333476 Free PMC article.

4

An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

Seth PP, Allerson CR, Berdeja A, Siwkowski A, Pallan PS, Gaus H, Prakash TP, Watt AT, Egli M, Swayze EE. Seth PP, et al. Among authors: prakash tp. J Am Chem Soc. 2010 Oct 27;132(42):14942-50. doi: 10.1021/ja105875e. J Am Chem Soc. 2010. PMID: 20886816 Free PMC article.

5

Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.

Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M. Pallan PS, et al. Among authors: prakash tp. Chem Commun (Camb). 2012 Aug 25;48(66):8195-7. doi: 10.1039/c2cc32286b. Epub 2012 May 22. Chem Commun (Camb). 2012. PMID: 22614180 Free PMC article.

6

Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.

Egli M, Minasov G, Tereshko V, Pallan PS, Teplova M, Inamati GB, Lesnik EA, Owens SR, Ross BS, Prakash TP, Manoharan M. Egli M, et al. Among authors: prakash tp. Biochemistry. 2005 Jun 28;44(25):9045-57. doi: 10.1021/bi050574m. Biochemistry. 2005. PMID: 15966728 Free article.

7

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.

Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M. Li F, et al. Among authors: prakash tp. Biochemistry. 2006 Apr 4;45(13):4141-52. doi: 10.1021/bi052322r. Biochemistry. 2006. PMID: 16566588 Free PMC article.

8

2'-Modified oligonucleotides for antisense therapeutics.

Prakash TP, Bhat B. Prakash TP, et al. Curr Top Med Chem. 2007;7(7):641-9. doi: 10.2174/156802607780487713. Curr Top Med Chem. 2007. PMID: 17430205 Review.

9

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Wancewicz EV, Witchell D, Swayze EE. Seth PP, et al. Among authors: prakash tp. J Med Chem. 2009 Jan 8;52(1):10-3. doi: 10.1021/jm801294h. J Med Chem. 2009. PMID: 19086780

10

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. Among authors: prakash tp. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

115 results

Search Page

Filters