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Page 1
Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).
Wager TT, Pettersen BA, Schmidt AW, Spracklin DK, Mente S, Butler TW, Howard H, Lettiere DJ, Rubitski DM, Wong DF, Nedza FM, Nelson FR, Rollema H, Raggon JW, Aubrecht J, Freeman JK, Marcek JM, Cianfrogna J, Cook KW, James LC, Chatman LA, Iredale PA, Banker MJ, Homiski ML, Munzner JB, Chandrasekaran RY. Wager TT, et al. Among authors: munzner jb. J Med Chem. 2011 Nov 10;54(21):7602-20. doi: 10.1021/jm200939b. Epub 2011 Oct 7. J Med Chem. 2011. PMID: 21928839
Development and validation of an in vitro micronucleus assay platform in TK6 cells.
Sobol Z, Homiski ML, Dickinson DA, Spellman RA, Li D, Scott A, Cheung JR, Coffing SL, Munzner JB, Sanok KE, Gunther WC, Dobo KL, Schuler M. Sobol Z, et al. Among authors: munzner jb. Mutat Res. 2012 Jul 4;746(1):29-34. doi: 10.1016/j.mrgentox.2012.02.005. Epub 2012 Mar 13. Mutat Res. 2012. PMID: 22445949
In silico methods combined with expert knowledge rule out mutagenic potential of pharmaceutical impurities: an industry survey.
Dobo KL, Greene N, Fred C, Glowienke S, Harvey JS, Hasselgren C, Jolly R, Kenyon MO, Munzner JB, Muster W, Neft R, Reddy MV, White AT, Weiner S. Dobo KL, et al. Among authors: munzner jb. Regul Toxicol Pharmacol. 2012 Apr;62(3):449-55. doi: 10.1016/j.yrtph.2012.01.007. Epub 2012 Jan 31. Regul Toxicol Pharmacol. 2012. PMID: 22321701
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.
Miller AA, Bundy GL, Mott JE, Skepner JE, Boyle TP, Harris DW, Hromockyj AE, Marotti KR, Zurenko GE, Munzner JB, Sweeney MT, Bammert GF, Hamel JC, Ford CW, Zhong WZ, Graber DR, Martin GE, Han F, Dolak LA, Seest EP, Ruble JC, Kamilar GM, Palmer JR, Banitt LS, Hurd AR, Barbachyn MR. Miller AA, et al. Among authors: munzner jb. Antimicrob Agents Chemother. 2008 Aug;52(8):2806-12. doi: 10.1128/AAC.00247-08. Epub 2008 Jun 2. Antimicrob Agents Chemother. 2008. PMID: 18519725 Free PMC article.
BACE2 functions as an alternative alpha-secretase in cells.
Yan R, Munzner JB, Shuck ME, Bienkowski MJ. Yan R, et al. Among authors: munzner jb. J Biol Chem. 2001 Sep 7;276(36):34019-27. doi: 10.1074/jbc.M105583200. Epub 2001 Jun 22. J Biol Chem. 2001. PMID: 11423558 Free article.