Wheelan P - Search Results

1

Discovery of a novel series of cyclic urea as potent CCR5 antagonists.

Duan M, Kazmierski WM, Tallant M, Jun JH, Edelstein M, Ferris R, Todd D, Wheelan P, Xiong Z. Duan M, et al. Among authors: wheelan p. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6381-5. doi: 10.1016/j.bmcl.2011.08.096. Epub 2011 Aug 28. Bioorg Med Chem Lett. 2011. PMID: 21930378

2

Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1.

Tallant MD, Duan M, Freeman GA, Ferris RG, Edelstein MP, Kazmierski WM, Wheelan PJ. Tallant MD, et al. Among authors: wheelan pj. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1394-8. doi: 10.1016/j.bmcl.2011.01.030. Epub 2011 Jan 11. Bioorg Med Chem Lett. 2011. PMID: 21292480

3

Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1.

Kazmierski WM, Aquino C, Chauder BA, Deanda F, Ferris R, Jones-Hertzog DK, Kenakin T, Koble CS, Watson C, Wheelan P, Yang H, Youngman M. Kazmierski WM, et al. Among authors: wheelan p. J Med Chem. 2008 Oct 23;51(20):6538-46. doi: 10.1021/jm800598a. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811134

4

[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring.

Duan M, Aquino C, Ferris R, Kazmierski WM, Kenakin T, Koble C, Wheelan P, Watson C, Youngman M. Duan M, et al. Among authors: wheelan p. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1610-3. doi: 10.1016/j.bmcl.2009.02.014. Epub 2009 Feb 10. Bioorg Med Chem Lett. 2009. PMID: 19233649

5

Discovery of N-benzyl-N'-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (I): optimization of the amine portion.

Duan M, Peckham J, Edelstein M, Ferris R, Kazmierski WM, Spaltenstein A, Wheelan P, Xiong Z. Duan M, et al. Among authors: wheelan p. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7397-400. doi: 10.1016/j.bmcl.2010.10.033. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2010. PMID: 21035337

6

Discovery of N-benzyl-N'-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (II): modification of the acyl portion.

Duan M, Peckham J, Edelstein M, Ferris R, Kazmierski WM, Spaltenstein A, Wheelan P, Xiong Z. Duan M, et al. Among authors: wheelan p. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7401-4. doi: 10.1016/j.bmcl.2010.10.042. Epub 2010 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 21055933

7

Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile.

Kazmierski WM, Anderson DL, Aquino C, Chauder BA, Duan M, Ferris R, Kenakin T, Koble CS, Lang DG, McIntyre MS, Peckham J, Watson C, Wheelan P, Spaltenstein A, Wire MB, Svolto A, Youngman M. Kazmierski WM, et al. Among authors: wheelan p. J Med Chem. 2011 Jun 9;54(11):3756-67. doi: 10.1021/jm200279v. Epub 2011 May 17. J Med Chem. 2011. PMID: 21539377

8

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats.

Duan M, Kazmierski WM, Chong PY, Deanda F, Edelstein M, Ferris R, Peckham J, Wheelan P, Xiong Z, Zhang H, Nishizawa R, Takaoka Y. Duan M, et al. Among authors: wheelan p. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6470-5. doi: 10.1016/j.bmcl.2011.08.080. Epub 2011 Aug 23. Bioorg Med Chem Lett. 2011. PMID: 21920742

9

Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1.

Gudmundsson KS, Boggs SD, Catalano JG, Svolto A, Spaltenstein A, Thomson M, Wheelan P, Jenkinson S. Gudmundsson KS, et al. Among authors: wheelan p. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6399-403. doi: 10.1016/j.bmcl.2009.09.056. Epub 2009 Sep 19. Bioorg Med Chem Lett. 2009. PMID: 19818609

10

Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.

Jenkinson S, Thomson M, McCoy D, Edelstein M, Danehower S, Lawrence W, Wheelan P, Spaltenstein A, Gudmundsson K. Jenkinson S, et al. Among authors: wheelan p. Antimicrob Agents Chemother. 2010 Feb;54(2):817-24. doi: 10.1128/AAC.01293-09. Epub 2009 Nov 30. Antimicrob Agents Chemother. 2010. PMID: 19949058 Free PMC article.

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