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Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells.
Kumar S, Singh BK, Arya P, Malhotra S, Thimmulappa R, Prasad AK, Van der Eycken E, Olsen CE, DePass AL, Biswal S, Parmar VS, Ghosh B. Kumar S, et al. Among authors: thimmulappa r. Eur J Med Chem. 2011 Nov;46(11):5498-511. doi: 10.1016/j.ejmech.2011.09.008. Epub 2011 Sep 16. Eur J Med Chem. 2011. PMID: 21955679
Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: structure-activity analysis.
Kumar S, Reddy L CS, Kumar Y, Kumar A, Singh BK, Kumar V, Malhotra S, Pandey MK, Jain R, Thimmulappa R, Sharma SK, Prasad AK, Biswal S, Van der Eycken E, DePass AL, Malhotra SV, Ghosh B, Parmar VS. Kumar S, et al. Among authors: thimmulappa r. Arch Pharm (Weinheim). 2012 May;345(5):368-77. doi: 10.1002/ardp.201100279. Epub 2011 Dec 20. Arch Pharm (Weinheim). 2012. PMID: 22190402
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Thimmulappa RK, et al. Antioxid Redox Signal. 2007 Nov;9(11):1963-70. doi: 10.1089/ars.2007.1745. Antioxid Redox Signal. 2007. PMID: 17822364 Free PMC article.
Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.
Malhotra D, Thimmulappa RK, Mercado N, Ito K, Kombairaju P, Kumar S, Ma J, Feller-Kopman D, Wise R, Barnes P, Biswal S. Malhotra D, et al. Among authors: thimmulappa rk. J Clin Invest. 2011 Nov;121(11):4289-302. doi: 10.1172/JCI45144. Epub 2011 Oct 17. J Clin Invest. 2011. Retraction in: J Clin Invest. 2014 Dec;124(12):5521. doi: 10.1172/JCI79606. PMID: 22005302 Free PMC article. Retracted.
70 results