Wang H - Search Results

1

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.

Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, Choi A, Ke H, Ma D, Yuan J. Liu J, et al. Among authors: wang h. Cell. 2011 Sep 30;147(1):223-34. doi: 10.1016/j.cell.2011.08.037. Cell. 2011. PMID: 21962518 Free PMC article.

2

Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity.

Ke H, Wang H. Ke H, et al. Among authors: wang h. Curr Top Med Chem. 2007;7(4):391-403. doi: 10.2174/156802607779941242. Curr Top Med Chem. 2007. PMID: 17305581 Review.

3

The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.

Wang H, Robinson H, Ke H. Wang H, et al. J Mol Biol. 2007 Aug 10;371(2):302-7. doi: 10.1016/j.jmb.2007.05.060. Epub 2007 May 26. J Mol Biol. 2007. PMID: 17582435 Free PMC article.

4

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies.

Chen G, Wang H, Robinson H, Cai J, Wan Y, Ke H. Chen G, et al. Among authors: wang h. Biochem Pharmacol. 2008 May 1;75(9):1717-28. doi: 10.1016/j.bcp.2008.01.019. Epub 2008 Feb 12. Biochem Pharmacol. 2008. PMID: 18346713 Free PMC article.

5

Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain.

Yan Z, Wang H, Cai J, Ke H. Yan Z, et al. Among authors: wang h. Protein Expr Purif. 2009 Mar;64(1):82-8. doi: 10.1016/j.pep.2008.10.005. Epub 2008 Oct 19. Protein Expr Purif. 2009. PMID: 18984055 Free PMC article.

6

Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.

Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H. Zheng S, et al. Among authors: wang h, wang b. J Med Chem. 2008 Dec 25;51(24):7673-88. doi: 10.1021/jm701635j. J Med Chem. 2008. PMID: 19049349 Free PMC article.

7

Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.

Wang H, Robinson H, Ke H. Wang H, et al. J Biol Chem. 2010 Dec 3;285(49):38149-56. doi: 10.1074/jbc.M110.141614. Epub 2010 Sep 21. J Biol Chem. 2010. PMID: 20861010 Free PMC article.

8

Structural insight into the substrate specificity of phosphodiesterases.

Ke H, Wang H, Ye M. Ke H, et al. Among authors: wang h. Handb Exp Pharmacol. 2011;(204):121-34. doi: 10.1007/978-3-642-17969-3_4. Handb Exp Pharmacol. 2011. PMID: 21695637 Review.

9

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.

Huai Q, Wang H, Liu Y, Kim HY, Toft D, Ke H. Huai Q, et al. Among authors: wang h. Structure. 2005 Apr;13(4):579-90. doi: 10.1016/j.str.2004.12.018. Structure. 2005. PMID: 15837196 Free article.

10

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

Wang H, Liu Y, Chen Y, Robinson H, Ke H. Wang H, et al. J Biol Chem. 2005 Sep 2;280(35):30949-55. doi: 10.1074/jbc.M504398200. Epub 2005 Jul 1. J Biol Chem. 2005. PMID: 15994308 Free article.

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