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Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species.
Liu HT, Du YG, He JL, Chen WJ, Li WM, Yang Z, Wang YX, Yu C. Liu HT, et al. Among authors: yang z. J Ethnopharmacol. 2010 Jun 16;129(3):335-43. doi: 10.1016/j.jep.2010.03.037. Epub 2010 Apr 3. J Ethnopharmacol. 2010. PMID: 20371283
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