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Histamine-driven responses are sustained via a bioactive metabolite.
Velez TE, Byrne AJ, Wechsler JB, Krier-Burris RA, Hulse KE, Bryce PJ. Velez TE, et al. Among authors: byrne aj. J Allergy Clin Immunol. 2019 Jun;143(6):2287-2290.e1. doi: 10.1016/j.jaci.2019.01.037. Epub 2019 Feb 8. J Allergy Clin Immunol. 2019. PMID: 30738840 Free PMC article. No abstract available.
Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.
Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM. Saglani S, et al. Sci Immunol. 2018 Sep 7;3(27):eaan4128. doi: 10.1126/sciimmunol.aan4128. Sci Immunol. 2018. PMID: 30194239 Free PMC article.
IRF5 regulates airway macrophage metabolic responses.
Albers GJ, Iwasaki J, McErlean P, Ogger PP, Ghai P, Khoyratty TE, Udalova IA, Lloyd CM, Byrne AJ. Albers GJ, et al. Among authors: byrne aj. Clin Exp Immunol. 2021 Apr;204(1):134-143. doi: 10.1111/cei.13573. Epub 2021 Jan 28. Clin Exp Immunol. 2021. PMID: 33423291 Free PMC article.
A critical role for IRF5 in regulating allergic airway inflammation.
Byrne AJ, Weiss M, Mathie SA, Walker SA, Eames HL, Saliba D, Lloyd CM, Udalova IA. Byrne AJ, et al. Mucosal Immunol. 2017 May;10(3):716-726. doi: 10.1038/mi.2016.92. Epub 2016 Oct 19. Mucosal Immunol. 2017. PMID: 27759022 Free PMC article.
Itaconate controls the severity of pulmonary fibrosis.
Ogger PP, Albers GJ, Hewitt RJ, O'Sullivan BJ, Powell JE, Calamita E, Ghai P, Walker SA, McErlean P, Saunders P, Kingston S, Molyneaux PL, Halket JM, Gray R, Chambers DC, Maher TM, Lloyd CM, Byrne AJ. Ogger PP, et al. Among authors: byrne aj. Sci Immunol. 2020 Oct 23;5(52):eabc1884. doi: 10.1126/sciimmunol.abc1884. Sci Immunol. 2020. PMID: 33097591 Free PMC article.
144 results