John M - Search Results

1

Delivery of siRNA to the mouse lung via a functionalized lipopolyamine.

Polach KJ, Matar M, Rice J, Slobodkin G, Sparks J, Congo R, Rea-Ramsey A, McClure D, Brunhoeber E, Krampert M, Schuster A, Jahn-Hofmann K, John M, Vornlocher HP, Fewell JG, Anwer K, Geick A. Polach KJ, et al. Among authors: john m. Mol Ther. 2012 Jan;20(1):91-100. doi: 10.1038/mt.2011.210. Epub 2011 Oct 11. Mol Ther. 2012. PMID: 21988874 Free PMC article.

2

Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection.

Wooddell CI, Rozema DB, Hossbach M, John M, Hamilton HL, Chu Q, Hegge JO, Klein JJ, Wakefield DH, Oropeza CE, Deckert J, Roehl I, Jahn-Hofmann K, Hadwiger P, Vornlocher HP, McLachlan A, Lewis DL. Wooddell CI, et al. Among authors: john m. Mol Ther. 2013 May;21(5):973-85. doi: 10.1038/mt.2013.31. Epub 2013 Feb 26. Mol Ther. 2013. PMID: 23439496 Free PMC article.

3

Gene silencing by RNAi in mammalian cells.

John M, Geick A, Hadwiger P, Vornlocher HP, Heidenreich O. John M, et al. Curr Protoc Mol Biol. 2003 May;Chapter 26:Unit 26.2. doi: 10.1002/0471142727.mb2602s62. Curr Protoc Mol Biol. 2003. PMID: 18265326

4

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells.

Lorenz C, Hadwiger P, John M, Vornlocher HP, Unverzagt C. Lorenz C, et al. Among authors: john m. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4975-7. doi: 10.1016/j.bmcl.2004.07.018. Bioorg Med Chem Lett. 2004. PMID: 15341962

5

Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab.

Höbel S, Koburger I, John M, Czubayko F, Hadwiger P, Vornlocher HP, Aigner A. Höbel S, et al. Among authors: john m. J Gene Med. 2010 Mar;12(3):287-300. doi: 10.1002/jgm.1431. J Gene Med. 2010. PMID: 20052738

6

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, John M, Kesavan V, Lavine G, Pandey RK, Racie T, Rajeev KG, Röhl I, Toudjarska I, Wang G, Wuschko S, Bumcrot D, Koteliansky V, Limmer S, Manoharan M, Vornlocher HP. Soutschek J, et al. Among authors: john m. Nature. 2004 Nov 11;432(7014):173-8. doi: 10.1038/nature03121. Nature. 2004. PMID: 15538359 Free article.

7

AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells.

Heidenreich O, Krauter J, Riehle H, Hadwiger P, John M, Heil G, Vornlocher HP, Nordheim A. Heidenreich O, et al. Among authors: john m. Blood. 2003 Apr 15;101(8):3157-63. doi: 10.1182/blood-2002-05-1589. Epub 2002 Dec 12. Blood. 2003. PMID: 12480707 Free article.

8

RNAi-mediated gene silencing in non-human primates.

Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Röhl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat AJ, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher HP, MacLachlan I. Zimmermann TS, et al. Among authors: john m. Nature. 2006 May 4;441(7089):111-4. doi: 10.1038/nature04688. Epub 2006 Mar 26. Nature. 2006. PMID: 16565705

9

Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro.

Broering R, Real CI, John MJ, Jahn-Hofmann K, Ickenstein LM, Kleinehr K, Paul A, Gibbert K, Dittmer U, Gerken G, Schlaak JF. Broering R, et al. Among authors: john mj. Int Immunol. 2014 Jan;26(1):35-46. doi: 10.1093/intimm/dxt040. Epub 2013 Sep 24. Int Immunol. 2014. PMID: 24065781

10

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.

John M, Constien R, Akinc A, Goldberg M, Moon YA, Spranger M, Hadwiger P, Soutschek J, Vornlocher HP, Manoharan M, Stoffel M, Langer R, Anderson DG, Horton JD, Koteliansky V, Bumcrot D. John M, et al. Nature. 2007 Oct 11;449(7163):745-7. doi: 10.1038/nature06179. Epub 2007 Sep 26. Nature. 2007. PMID: 17898712 Free PMC article.

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