Wideburg N - Search Results

1

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.

Erickson J, Neidhart DJ, VanDrie J, Kempf DJ, Wang XC, Norbeck DW, Plattner JJ, Rittenhouse JW, Turon M, Wideburg N, et al. Erickson J, et al. Among authors: wideburg n. Science. 1990 Aug 3;249(4968):527-33. doi: 10.1126/science.2200122. Science. 1990. PMID: 2200122

2

Structure-based, C2 symmetric inhibitors of HIV protease.

Kempf DJ, Norbeck DW, Codacovi L, Wang XC, Kohlbrenner WE, Wideburg NE, Paul DA, Knigge MF, Vasavanonda S, Craig-Kennard A, et al. Kempf DJ, et al. Among authors: wideburg ne. J Med Chem. 1990 Oct;33(10):2687-9. doi: 10.1021/jm00172a002. J Med Chem. 1990. PMID: 2213822 No abstract available.

3

Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.

Kempf DJ, Codacovi L, Wang XC, Kohlbrenner WE, Wideburg NE, Saldivar A, Vasavanonda S, Marsh KC, Bryant P, Sham HL, et al. Kempf DJ, et al. Among authors: wideburg ne. J Med Chem. 1993 Feb 5;36(3):320-30. doi: 10.1021/jm00055a003. J Med Chem. 1993. PMID: 8426362

4

A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.

Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W Jr, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: wideburg ne. J Med Chem. 1996 Jan 19;39(2):392-7. doi: 10.1021/jm9507183. J Med Chem. 1996. PMID: 8558507

5

Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.

Sham HL, Zhao C, Marsh KC, Betebenner DA, Lin S, Rosenbrook W Jr, Herrin T, Li L, Madigan D, Vasavanonda S, Molla A, Saldivar A, McDonald E, Wideburg NE, Kempf D, Norbeck DW, Plattner JJ. Sham HL, et al. Among authors: wideburg ne. Biochem Biophys Res Commun. 1996 Aug 14;225(2):436-40. doi: 10.1006/bbrc.1996.1191. Biochem Biophys Res Commun. 1996. PMID: 8753780

6

Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.

Kempf DJ, Sham HL, Marsh KC, Flentge CA, Betebenner D, Green BE, McDonald E, Vasavanonda S, Saldivar A, Wideburg NE, Kati WM, Ruiz L, Zhao C, Fino L, Patterson J, Molla A, Plattner JJ, Norbeck DW. Kempf DJ, et al. Among authors: wideburg ne. J Med Chem. 1998 Feb 12;41(4):602-17. doi: 10.1021/jm970636+. J Med Chem. 1998. PMID: 9484509

7

Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores.

Wang GT, Li S, Wideburg N, Krafft GA, Kempf DJ. Wang GT, et al. Among authors: wideburg n. J Med Chem. 1995 Aug 4;38(16):2995-3002. doi: 10.1021/jm00016a001. J Med Chem. 1995. PMID: 7636862

8

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.

Chen X, Kempf DJ, Li L, Sham HL, Vasavanonda S, Wideburg NE, Saldivar A, Marsh KC, McDonald E, Norbeck DW. Chen X, et al. Among authors: wideburg ne. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3657-60. doi: 10.1016/j.bmcl.2003.08.043. Bioorg Med Chem Lett. 2003. PMID: 14552751

9

Potent HIV-1 protease inhibitors with antiviral activities in vitro.

Sham HL, Betebenner DA, Wideburg NE, Saldivar AC, Kohlbrenner WE, Vasavanonda S, Kempf DJ, Norbeck DW, Zhao C, Clement JJ, et al. Sham HL, et al. Among authors: wideburg ne. Biochem Biophys Res Commun. 1991 Mar 29;175(3):914-9. doi: 10.1016/0006-291x(91)91652-s. Biochem Biophys Res Commun. 1991. PMID: 2025263

10

Design of orally bioavailable, symmetry-based inhibitors of HIV protease.

Kempf DJ, Marsh KC, Fino LC, Bryant P, Craig-Kennard A, Sham HL, Zhao C, Vasavanonda S, Kohlbrenner WE, Wideburg NE, et al. Kempf DJ, et al. Among authors: wideburg ne. Bioorg Med Chem. 1994 Sep;2(9):847-58. doi: 10.1016/s0968-0896(00)82036-2. Bioorg Med Chem. 1994. PMID: 7712122

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