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Page 1
Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.
Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, Van Kampen A, Rider MH, Takemori H, van Dijk KW, Van Veldhoven PP, Carmeliet P, Baes M. Peeters A, et al. Among authors: fraisl p. J Biol Chem. 2011 Dec 9;286(49):42162-42179. doi: 10.1074/jbc.M111.299727. Epub 2011 Oct 14. J Biol Chem. 2011. PMID: 22002056 Free PMC article.
Oxygen sensors at the crossroad of metabolism.
Aragonés J, Fraisl P, Baes M, Carmeliet P. Aragonés J, et al. Among authors: fraisl p. Cell Metab. 2009 Jan 7;9(1):11-22. doi: 10.1016/j.cmet.2008.10.001. Cell Metab. 2009. PMID: 19117543 Free article. Review.
Regulation of angiogenesis by oxygen and metabolism.
Fraisl P, Mazzone M, Schmidt T, Carmeliet P. Fraisl P, et al. Dev Cell. 2009 Feb;16(2):167-79. doi: 10.1016/j.devcel.2009.01.003. Dev Cell. 2009. PMID: 19217420 Free article. Review.
Role of PFKFB3-driven glycolysis in vessel sprouting.
De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P. De Bock K, et al. Among authors: fraisl p. Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037. Cell. 2013. PMID: 23911327 Free article.
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.
Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P. Aragonés J, et al. Among authors: fraisl p. Nat Genet. 2008 Feb;40(2):170-80. doi: 10.1038/ng.2007.62. Epub 2008 Jan 6. Nat Genet. 2008. PMID: 18176562 Free article.
Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.
Fitzpatrick SF, Fábián Z, Schaible B, Lenihan CR, Schwarzl T, Rodriguez J, Zheng X, Li Z, Tambuwala MM, Higgins DG, O'Meara Y, Slattery C, Manresa MC, Fraisl P, Bruning U, Baes M, Carmeliet P, Doherty G, von Kriegsheim A, Cummins EP, Taylor CT. Fitzpatrick SF, et al. Among authors: fraisl p. Biochem Biophys Res Commun. 2016 Jun 3;474(3):579-586. doi: 10.1016/j.bbrc.2016.04.085. Epub 2016 Apr 27. Biochem Biophys Res Commun. 2016. PMID: 27130823 Free article.
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.
Schneider M, Van Geyte K, Fraisl P, Kiss J, Aragonés J, Mazzone M, Mairbäurl H, De Bock K, Jeoung NH, Mollenhauer M, Georgiadou M, Bishop T, Roncal C, Sutherland A, Jordan B, Gallez B, Weitz J, Harris RA, Maxwell P, Baes M, Ratcliffe P, Carmeliet P. Schneider M, et al. Among authors: fraisl p. Gastroenterology. 2010 Mar;138(3):1143-54.e1-2. doi: 10.1053/j.gastro.2009.09.057. Epub 2009 Oct 8. Gastroenterology. 2010. PMID: 19818783 Free article.
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. Schmidt T, et al. Among authors: fraisl p. Cancer Cell. 2011 Jun 14;19(6):740-53. doi: 10.1016/j.ccr.2011.05.007. Cancer Cell. 2011. PMID: 21665148 Free article.
24 results