LoGrasso P - Search Results

1

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

Chowdhury S, Sessions EH, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, Schürer S, LoGrasso P, Bannister TD, Feng Y. Chowdhury S, et al. Among authors: lograsso p. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7107-12. doi: 10.1016/j.bmcl.2011.09.083. Epub 2011 Sep 24. Bioorg Med Chem Lett. 2011. PMID: 22004718

2

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.

Noël R, Shin Y, Song X, He Y, Koenig M, Chen W, Ling YY, Lin L, Ruiz CH, LoGrasso P, Cameron MD, Duckett DR, Kamenecka TM. Noël R, et al. Among authors: lograsso p. Bioorg Med Chem Lett. 2011 May 1;21(9):2732-5. doi: 10.1016/j.bmcl.2010.11.104. Epub 2010 Dec 1. Bioorg Med Chem Lett. 2011. PMID: 21185177 Free PMC article.

3

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

Kamenecka T, Jiang R, Song X, Duckett D, Chen W, Ling YY, Habel J, Laughlin JD, Chambers J, Figuera-Losada M, Cameron MD, Lin L, Ruiz CH, LoGrasso PV. Kamenecka T, et al. J Med Chem. 2010 Jan 14;53(1):419-31. doi: 10.1021/jm901351f. J Med Chem. 2010. PMID: 19947601 Free PMC article.

4

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.

He Y, Kamenecka TM, Shin Y, Song X, Jiang R, Noel R, Duckett D, Chen W, Ling YY, Cameron MD, Lin L, Khan S, Koenig M, LoGrasso PV. He Y, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1719-23. doi: 10.1016/j.bmcl.2011.01.079. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21316221 Free PMC article.

5

Amino acid derived quinazolines as Rock/PKA inhibitors.

Chowdhury S, Chen YT, Fang X, Grant W, Pocas J, Cameron MD, Ruiz C, Lin L, Park H, Schröter T, Bannister TD, Lograsso PV, Feng Y. Chowdhury S, et al. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1592-9. doi: 10.1016/j.bmcl.2013.01.109. Epub 2013 Jan 31. Bioorg Med Chem Lett. 2013. PMID: 23416002

6

Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.

Yin Y, Lin L, Ruiz C, Khan S, Cameron MD, Grant W, Pocas J, Eid N, Park H, Schröter T, Lograsso PV, Feng Y. Yin Y, et al. J Med Chem. 2013 May 9;56(9):3568-81. doi: 10.1021/jm400062r. Epub 2013 Apr 25. J Med Chem. 2013. PMID: 23570561

7

Rho kinase inhibitors: a patent review (2012 - 2013).

Feng Y, LoGrasso PV. Feng Y, et al. Expert Opin Ther Pat. 2014 Mar;24(3):295-307. doi: 10.1517/13543776.2014.863279. Epub 2013 Nov 27. Expert Opin Ther Pat. 2014. PMID: 24283930 Review.

8

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.

He Y, Duckett D, Chen W, Ling YY, Cameron MD, Lin L, Ruiz CH, Lograsso PV, Kamenecka TM, Koenig M. He Y, et al. Among authors: lograsso pv. Bioorg Med Chem Lett. 2014 Jan 1;24(1):161-4. doi: 10.1016/j.bmcl.2013.11.052. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332487 Free PMC article.

9

Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.

Zheng K, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y. Zheng K, et al. Among authors: lograsso pv. J Med Chem. 2014 Dec 11;57(23):10013-30. doi: 10.1021/jm501256y. Epub 2014 Nov 21. J Med Chem. 2014. PMID: 25393557 Free PMC article.

10

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.

Feng Y, LoGrasso PV, Defert O, Li R. Feng Y, et al. Among authors: lograsso pv. J Med Chem. 2016 Mar 24;59(6):2269-300. doi: 10.1021/acs.jmedchem.5b00683. Epub 2015 Oct 30. J Med Chem. 2016. PMID: 26486225 Review.

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