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Adding thiazide to a renin-angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension.
Ito H, Ishii K, Kihara H, Kasayuki N, Nakamura F, Shimada K, Fukuda S, Iwakura K, Yoshikawa J; Effect of ARB/Diuretics on Diastolic Function in Patients with Hypertension (EDEN) trial investigators. Ito H, et al. Hypertens Res. 2012 Jan;35(1):93-9. doi: 10.1038/hr.2011.169. Epub 2011 Oct 20. Hypertens Res. 2012. PMID: 22011686 Free PMC article. Clinical Trial.
Effect of Diuretic or Calcium-Channel Blocker Plus Angiotensin-Receptor Blocker on Diastolic Function in Hypertensive Patients.
Toh N, Ishii K, Kihara H, Iwakura K, Watanabe H, Yoshikawa J, Ito H; Effect of ARB/Diuretics on Diastolic Function in Patients with Hypertension 2 (EDEN2) trial investigators. Toh N, et al. Among authors: ito h. Circ J. 2016;80(2):426-34. doi: 10.1253/circj.CJ-15-0815. Epub 2015 Dec 25. Circ J. 2016. PMID: 26725762 Free article. Clinical Trial.
Changes in left ventricular relaxation after azelnidipine treatment in hypertensive patients with diabetes: subanalysis of a prospective single-arm multicentre study.
Iwakura K, Ito H, Ishii K, Date M, Nakamura F, Nagano T, Takiuchi S; Clinical impact of Azelnidipine on Left VentricuLar diastolic function and OutComes in patients with hypertension (CALVLOC) trial investigators. Iwakura K, et al. Among authors: ito h. BMJ Open. 2014 Sep 30;4(9):e006136. doi: 10.1136/bmjopen-2014-006136. BMJ Open. 2014. PMID: 25270860 Free PMC article. Clinical Trial.
Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial.
Oe H, Nakamura K, Kihara H, Shimada K, Fukuda S, Takagi T, Miyoshi T, Hirata K, Yoshikawa J, Ito H; FESC, for Effect of a DPP-4 inhibitor on left ventricular diastolic dysfunction in patients with type 2 diabetes and diabetic cardiomyopathy (3D) study investigators. Oe H, et al. Among authors: ito h. Cardiovasc Diabetol. 2015 Jun 19;14:83. doi: 10.1186/s12933-015-0242-z. Cardiovasc Diabetol. 2015. PMID: 26084668 Free PMC article. Clinical Trial.
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