Harper JW - Search Results

1

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. Gao D, et al. Among authors: harper jw. Mol Cell. 2011 Oct 21;44(2):290-303. doi: 10.1016/j.molcel.2011.08.030. Mol Cell. 2011. PMID: 22017875 Free PMC article.

2

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW. Jin J, et al. Among authors: harper jw. Genes Dev. 2003 Dec 15;17(24):3062-74. doi: 10.1101/gad.1157503. Epub 2003 Dec 17. Genes Dev. 2003. PMID: 14681206 Free PMC article.

3

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

Harper JW. Harper JW. Cell. 2004 Jul 9;118(1):2-4. doi: 10.1016/j.cell.2004.06.015. Cell. 2004. PMID: 15242638 Free article.

4

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW. Ye X, et al. Among authors: harper jw. J Biol Chem. 2004 Nov 26;279(48):50110-9. doi: 10.1074/jbc.M409226200. Epub 2004 Sep 13. J Biol Chem. 2004. PMID: 15364936 Free article.

5

SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.

Shirogane T, Jin J, Ang XL, Harper JW. Shirogane T, et al. Among authors: harper jw. J Biol Chem. 2005 Jul 22;280(29):26863-72. doi: 10.1074/jbc.M502862200. Epub 2005 May 24. J Biol Chem. 2005. PMID: 15917222 Free article.

6

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.

Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr. Wei W, et al. Among authors: harper jw. Cancer Cell. 2005 Jul;8(1):25-33. doi: 10.1016/j.ccr.2005.06.005. Cancer Cell. 2005. PMID: 16023596 Free article.

7

Structural complexity in ubiquitin recognition.

Harper JW, Schulman BA. Harper JW, et al. Cell. 2006 Mar 24;124(6):1133-6. doi: 10.1016/j.cell.2006.03.009. Cell. 2006. PMID: 16564007 Free article. Review.

8

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

Jin J, Arias EE, Chen J, Harper JW, Walter JC. Jin J, et al. Among authors: harper jw. Mol Cell. 2006 Sep 1;23(5):709-21. doi: 10.1016/j.molcel.2006.08.010. Mol Cell. 2006. PMID: 16949367 Free article.

9

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.

Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA. Lin DI, et al. Among authors: harper jw. Mol Cell. 2006 Nov 3;24(3):355-66. doi: 10.1016/j.molcel.2006.09.007. Mol Cell. 2006. PMID: 17081987 Free PMC article.

10

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP. Hao B, et al. Among authors: harper jw. Mol Cell. 2007 Apr 13;26(1):131-43. doi: 10.1016/j.molcel.2007.02.022. Mol Cell. 2007. PMID: 17434132 Free article.

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