Hamel E - Search Results

1

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.

Romagnoli R, Baraldi PG, Lopez Cara C, Kimatrai Salvador M, Bortolozzi R, Basso G, Viola G, Balzarini J, Brancale A, Fu XH, Li J, Zhang SZ, Hamel E. Romagnoli R, et al. Among authors: hamel e. Eur J Med Chem. 2011 Dec;46(12):6015-24. doi: 10.1016/j.ejmech.2011.10.013. Epub 2011 Oct 15. Eur J Med Chem. 2011. PMID: 22027100 Free PMC article.

2

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1991 Aug;34(8):2579-88. doi: 10.1021/jm00112a036. J Med Chem. 1991. PMID: 1875350

3

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.

Jiang JB, Hesson DP, Dusak BA, Dexter DL, Kang GJ, Hamel E. Jiang JB, et al. Among authors: hamel e. J Med Chem. 1990 Jun;33(6):1721-8. doi: 10.1021/jm00168a029. J Med Chem. 1990. PMID: 2088342

4

Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.

Li L, Wang HK, Kuo SC, Wu TS, Mauger A, Lin CM, Hamel E, Lee KH. Li L, et al. Among authors: hamel e. J Med Chem. 1994 Sep 30;37(20):3400-7. doi: 10.1021/jm00046a025. J Med Chem. 1994. PMID: 7932568

5

Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.

Cushman M, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1993 Sep 17;36(19):2817-21. doi: 10.1021/jm00071a012. J Med Chem. 1993. PMID: 8410995

6

Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.

Sun L, Hamel E, Lin CM, Hastie SB, Pyluck A, Lee KH. Sun L, et al. Among authors: hamel e. J Med Chem. 1993 May 14;36(10):1474-9. doi: 10.1021/jm00062a021. J Med Chem. 1993. PMID: 8496915

7

Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.

Sun L, McPhail AT, Hamel E, Lin CM, Hastie SB, Chang JJ, Lee KH. Sun L, et al. Among authors: hamel e. J Med Chem. 1993 Mar 5;36(5):544-51. doi: 10.1021/jm00057a004. J Med Chem. 1993. PMID: 8496935

8

Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.

Chen K, Kuo SC, Hsieh MC, Mauger A, Lin CM, Hamel E, Lee KH. Chen K, et al. Among authors: hamel e. J Med Chem. 1997 Sep 12;40(19):3049-56. doi: 10.1021/jm970146h. J Med Chem. 1997. PMID: 9301667

9

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).

Kingston DG, Chaudhary AG, Chordia MD, Gharpure M, Gunatilaka AA, Higgs PI, Rimoldi JM, Samala L, Jagtap PG, Giannakakou P, Jiang YQ, Lin CM, Hamel E, Long BH, Fairchild CR, Johnston KA. Kingston DG, et al. Among authors: hamel e. J Med Chem. 1998 Sep 10;41(19):3715-26. doi: 10.1021/jm980229d. J Med Chem. 1998. PMID: 9733497

10

Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization.

Pieters L, Van Dyck S, Gao M, Bai R, Hamel E, Vlietinck A, Lemière G. Pieters L, et al. Among authors: hamel e. J Med Chem. 1999 Dec 30;42(26):5475-81. doi: 10.1021/jm990251m. J Med Chem. 1999. PMID: 10639289

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