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Page 1
Bugs, drugs and chemical genomics.
Roemer T, Davies J, Giaever G, Nislow C. Roemer T, et al. Nat Chem Biol. 2011 Dec 15;8(1):46-56. doi: 10.1038/nchembio.744. Nat Chem Biol. 2011. PMID: 22173359 Review.
PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.
Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu W, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Pelaez F, Diez MT, Kauffman S, Becker J, Harris G, Liberator P, Roemer T. Jiang B, et al. Among authors: roemer t. Chem Biol. 2008 Apr;15(4):363-74. doi: 10.1016/j.chembiol.2008.02.016. Chem Biol. 2008. PMID: 18420143
Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.
Xu D, Sillaots S, Davison J, Hu W, Jiang B, Kauffman S, Martel N, Ocampo P, Oh C, Trosok S, Veillette K, Wang H, Yang M, Zhang L, Becker J, Martin CE, Roemer T. Xu D, et al. Among authors: roemer t. J Biol Chem. 2009 Jul 17;284(29):19754-64. doi: 10.1074/jbc.M109.019877. Epub 2009 Jun 1. J Biol Chem. 2009. PMID: 19487691 Free PMC article.
Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus.
Rodriguez-Suarez R, Xu D, Veillette K, Davison J, Sillaots S, Kauffman S, Hu W, Bowman J, Martel N, Trosok S, Wang H, Zhang L, Huang LY, Li Y, Rahkhoodaee F, Ransom T, Gauvin D, Douglas C, Youngman P, Becker J, Jiang B, Roemer T. Rodriguez-Suarez R, et al. Among authors: roemer t. Chem Biol. 2007 Oct;14(10):1163-75. doi: 10.1016/j.chembiol.2007.09.009. Chem Biol. 2007. PMID: 17961828
Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.
Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T. Mann PA, et al. Among authors: roemer t. ACS Infect Dis. 2015 Jan 9;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12. ACS Infect Dis. 2015. PMID: 26878058 Free PMC article.
Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.
Wang H, Gill CJ, Lee SH, Mann P, Zuck P, Meredith TC, Murgolo N, She X, Kales S, Liang L, Liu J, Wu J, Santa Maria J, Su J, Pan J, Hailey J, Mcguinness D, Tan CM, Flattery A, Walker S, Black T, Roemer T. Wang H, et al. Among authors: roemer t. Chem Biol. 2013 Feb 21;20(2):272-84. doi: 10.1016/j.chembiol.2012.11.013. Chem Biol. 2013. PMID: 23438756 Free PMC article.
83 results